A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample
文献类型：期刊论文
| 作者 | Lin, XP ; Zhou, XF ; Wang, FZ ; Liu, KS ; Yang, B ; Yang, XW ; Peng, Y ; Liu, J ; Ren, Z ; Liu, YH |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2012 |
| 卷号 | 10期号:1页码:106-115 |
| 关键词 | Penicillium sp F00120 sesquiterpene quinone cytotoxic deep sea sediment penicilliumin A |
| ISSN号 | 1660-3397 |
| 通讯作者 | xiupinglin@hotmail.com ; xfzhou@scsio.ac.cn ; wangfazuo@scsio.ac.cn ; liukaisheng1987@163.com ; bingo525@163.com ; xwyang@scsio.ac.cn ; py00_2006@126.com ; ljuan2010@qq.com ; rz62@163.com ; yonghongliu@scsio.ac.cn |
| 中文摘要 | A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately. |
| 学科主题 | Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000299541800007 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10022]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Lin, XP,Zhou, XF,Wang, FZ,et al. A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample[J]. MARINE DRUGS,2012,10(1):106-115. |
| APA | Lin, XP.,Zhou, XF.,Wang, FZ.,Liu, KS.,Yang, B.,...&Liu, YH.(2012).A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample.MARINE DRUGS,10(1),106-115. |
| MLA | Lin, XP,et al."A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample".MARINE DRUGS 10.1(2012):106-115. |
入库方式： OAI收割
来源：南海海洋研究所
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