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Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology
文献类型：期刊论文
| 作者 | Gao, H ; Liu, M ; Liu, JT ; Dai, HQ ; Zhou, XL ; Liu, XY ; Zhuo, Y ; Zhang, WQ ; Zhang, LX |
| 刊名 | BIORESOURCE TECHNOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 100期号:17页码:4012-4016 |
| 关键词 | Streptomyces avermitilis Avermectin B1a Medium optimization Response surface |
| ISSN号 | 0960-8524 |
| 通讯作者 | Zhanglixin@im.ac.cn |
| 中文摘要 | Response surface methodology was employed to optimize the composition of medium for the production of avermectin B1a by Streptomyces avermitilis 14-12A in shaker flask cultivation. Corn starch and yeast extract were found to have significant effects on avermectin B1a production by the Plackett-Burman design. The steepest ascent method was used to access the optimal region of the medium composition, followed by an application of response surface. The analysis revealed that the optimum values of the tested variables were 149.57 g/l corn starch and 8.92 g/l yeast extract. A production of 5128 mg/l, which was in agreement with the prediction, was observed in verification experiment. In comparison to the production of original level (3528 mg/l), 1.45-fold increase had been obtained. (C) 2009 Elsevier Ltd. All rights reserved. |
| 学科主题 | Agricultural Engineering; Biotechnology & Applied Microbiology; Energy & Fuels |
| 收录类别 | SCI |
| 原文出处 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000266752200025 |
| 公开日期 | 2011-07-03 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/5390]  |
| 专题 | 南海海洋研究所_海洋生物 |
| 推荐引用方式 GB/T 7714 | Gao, H,Liu, M,Liu, JT,et al. Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology[J]. BIORESOURCE TECHNOLOGY,2009,100(17):4012-4016. |
| APA | Gao, H.,Liu, M.,Liu, JT.,Dai, HQ.,Zhou, XL.,...&Zhang, LX.(2009).Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology.BIORESOURCE TECHNOLOGY,100(17),4012-4016. |
| MLA | Gao, H,et al."Medium optimization for the production of avermectin B1a by Streptomyces avermitilis 14-12A using response surface methodology".BIORESOURCE TECHNOLOGY 100.17(2009):4012-4016. |
入库方式： OAI收割
来源：南海海洋研究所
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