Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China
文献类型：期刊论文
| 作者 | Dun-Lian Qiu
|
| 刊名 | Biochemical Genetics
 |
| 出版日期 | 2007-04 |
| 卷号 | 45期号:3/4页码:281-290 |
| 关键词 | Mycobacterium tuberculosis multidrug resistant gene mutation sequence. |
| 通讯作者 | Zhi-Rong Yang |
| 英文摘要 | DNA sequencing analysis was used to investigate genetic alterations in the rpoB, katG, and inhA regulatory region and embB in 66 Mycobacterium tuberculosis isolates recovered from Central China. Of the 36 multidrug-resistant isolates, 33 (92%) had mutations in the amplified region of rpoB. The most frequent mutation (58%, 19/36) was S531L (TCG→TTG). At least one mutation was found in the katG and inhA regulatory region in 83% (30/36) of the multidrug-resistant isolates, and mutations at katG codon 315 were identified in 78% (28/36). Alterations at embB306 may not confer resistance to EMB, and embB306 mutants were more frequently accompanied by rpoB mutations (100%, 16/16) than by katG 315 mutations (75%, 12/16). Our results show that geographic variation in the molecular genetic mechanism is responsible for drug resistance in multidrug-resistant M. tuberculosis. This observation will facilitate the development of a rapid molecular drug resistance screening approach for drug-resistant M. tuberculosis. |
| 学科主题 | 其他学科 |
| 语种 | 英语 |
| 公开日期 | 2012-06-26 |
| 源URL | [http://192.168.143.20:8080/handle/131551/4064]  |
| 专题 | 成都山地灾害与环境研究所_管理与支撑系统 科技信息与传播中心 |
| 推荐引用方式 GB/T 7714 | Dun-Lian Qiu. Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China[J]. Biochemical Genetics,2007,45(3/4):281-290. |
| APA | Dun-Lian Qiu.(2007).Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China.Biochemical Genetics,45(3/4),281-290. |
| MLA | Dun-Lian Qiu."Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China".Biochemical Genetics 45.3/4(2007):281-290. |
入库方式： OAI收割
来源：成都山地灾害与环境研究所
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