Evaluating genotoxicity associated with microcystin-LR and its risk to source water safety in Meiliang Bay, Taihu Lake
文献类型：期刊论文
| 作者 | Wu, JY; Xu, QJ; Gao, G; Shen, JH |
| 刊名 | ENVIRONMENTAL TOXICOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 21期号:3页码:250-255 |
| 关键词 | Taihu Lake microcystin-LR genotoxicity risk assessment drinking water |
| ISSN号 | 1520-4081 |
| 英文摘要 | In recent years cyanobacteria blooms have become a severe problem in Taihu Lake, a large shallow eutrophic lake in China. Microcystins produced by certain genera of cyanobacteria can affect public health in this area because of their acute and chronic toxic effects. In this study, samples of cyanobacteria were collected and extracted by two solvent systems. The extracts were tested with three short-term genotoxicity assays, the ara test, the Ames test, and the SOS/umu test. In addition, temporal variation in the concentrations of microcystin-LR in the water samples was determined and monitored by an ELISA assay. Then the concentration of microcystin-LR in the drinking water was estimated. The risk of microcystin-LR exposure by drinking water was assessed according to tolerable daily intake (TDI). The three genotoxicity assays showed negative results regardless of the solvent system used, and there were clear inconsistencies in the spatiotemporal profiles of genotoxic potential and microcystin concentrations in Taihu Lake. Risk assessment showed that the drinking water from Taihu Lake was not safe from the end of July to the beginning of November because of a high concentration of microcystin-LR. Our study indicated the drinking water from Taihu Lake posed a risk because of the microcystin-LR, although it was neither genotoxic nor associated with genotoxicity of the lake water. (c) 2006 Wiley Periodicals, Inc. |
| 公开日期 | 2012-03-08 |
| 源URL | [http://159.226.73.51/handle/332005/2973]  |
| 专题 | 南京地理与湖泊研究所_湖泊室 |
| 推荐引用方式 GB/T 7714 | Wu, JY,Xu, QJ,Gao, G,et al. Evaluating genotoxicity associated with microcystin-LR and its risk to source water safety in Meiliang Bay, Taihu Lake[J]. ENVIRONMENTAL TOXICOLOGY,2006,21(3):250-255. |
| APA | Wu, JY,Xu, QJ,Gao, G,&Shen, JH.(2006).Evaluating genotoxicity associated with microcystin-LR and its risk to source water safety in Meiliang Bay, Taihu Lake.ENVIRONMENTAL TOXICOLOGY,21(3),250-255. |
| MLA | Wu, JY,et al."Evaluating genotoxicity associated with microcystin-LR and its risk to source water safety in Meiliang Bay, Taihu Lake".ENVIRONMENTAL TOXICOLOGY 21.3(2006):250-255. |
入库方式： OAI收割
来源：南京地理与湖泊研究所
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