Targets of Danshen's Active Components for Activating Blood Circulation Activities
文献类型：期刊论文
| 作者 | Liu Hai-Bo2; Xu Jun1; Peng Yong2; Zhou Jia-Ju3; Xiao Pei-Gen2 |
| 刊名 | ACTA PHYSICO-CHIMICA SINICA
 |
| 出版日期 | 2010 |
| 卷号 | 26期号:1页码:199-205 |
| 关键词 | Drug target Salvia miltiorrhiza bunge (Danshen) Danshensu Traditional Chinese medicine Activating blood |
| ISSN号 | 1000-6818 |
| 通讯作者 | Xu, J |
| 英文摘要 | The active components in salvia miltiorrhiza bunge (danshen) include danshensu, labiatenic acid, and tanshinone, and they are known to be key compounds for danshen's blood-activating effect in traditional Chinese medicine. Studies show that these compounds have some common scaffolds. A systematic investigation was conducted to locate the targets of these active components among proteins with reported crystal structures. A structural informatics knowledgebase derived from protein structure and ligand-binding mode information was employed in this investigation. Furthermore, docking methods were used to rationally discover the relationship between the scaffold characteristics and the binding ability with the proteins. Results indicate that the active components comprehensively inhibit the metabolic network of adrenaline, which is a strong endogenetic cardiovascular activator. Consequently, adrenaline and its derivatives are accumulated and blood circulation is activated. We propose that key enzymes in the metabolic pathway of adrenaline including phenylethanolamine N-methyltransferase, catechol O-methyltransferase, and monoamine oxidases are targets for the active components in danshen. This research aids in the understanding of the mechanism of danshen's activating blood action. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CATECHOL-O-METHYLTRANSFERASE ; TANDEM MASS-SPECTROMETRY ; RAT CORONARY-ARTERY ; SALVIA-MILTIORRHIZA ; CRYSTAL-STRUCTURES ; CALCIUM-CHANNELS ; INHIBITION ; EXTRACT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273849300032 |
| 公开日期 | 2013-11-27 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6237]  |
| 专题 | 过程工程研究所_多相复杂系统国家重点实验室 |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China 2.Chinese Acad Med Sci, Inst Med Plant Dev, Peking Union Med Coll, Beijing 100193, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Hai-Bo,Xu Jun,Peng Yong,et al. Targets of Danshen's Active Components for Activating Blood Circulation Activities[J]. ACTA PHYSICO-CHIMICA SINICA,2010,26(1):199-205. |
| APA | Liu Hai-Bo,Xu Jun,Peng Yong,Zhou Jia-Ju,&Xiao Pei-Gen.(2010).Targets of Danshen's Active Components for Activating Blood Circulation Activities.ACTA PHYSICO-CHIMICA SINICA,26(1),199-205. |
| MLA | Liu Hai-Bo,et al."Targets of Danshen's Active Components for Activating Blood Circulation Activities".ACTA PHYSICO-CHIMICA SINICA 26.1(2010):199-205. |
入库方式： OAI收割
来源：过程工程研究所
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