Explicit solvent molecular dynamics simulations of chaperonin-assisted rhodanese folding
文献类型：期刊论文
| 作者 | Ren, Ying1,2; Gao, Jian1; Xu, Ji1,2; Ge, Wei1; Li, Jinghai1 |
| 刊名 | PARTICUOLOGY
 |
| 出版日期 | 2009-06-01 |
| 卷号 | 7期号:3页码:220-224 |
| 关键词 | Molecular dynamics simulation Explicit solvent Chaperonin-assisted Protein folding Molecular chaperonin Rhodanese |
| ISSN号 | 1674-2001 |
| 通讯作者 | Gao, J |
| 英文摘要 | Chaperonins are known to facilitate the productive folding of numerous misfolded proteins. Despite their established importance, the mechanism of chaperonin-assisted protein folding remains unknown. In the present article, all-atom explicit solvent molecular dynamics (MD) simulations have been performed for the first time on rhodanese folding in a series of cavity-size and cavity-charge chaperonin mutants. A compromise between stability and flexibility of chaperonin structure during the substrate folding has been observed and the key factors affecting this dynamic process are discussed. (C) 2009 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Chemical ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | PROTEIN ; COMPLEX ; CAGE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266862500010 |
| 公开日期 | 2013-12-09 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6665]  |
| 专题 | 过程工程研究所_多相复杂系统国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Ying,Gao, Jian,Xu, Ji,et al. Explicit solvent molecular dynamics simulations of chaperonin-assisted rhodanese folding[J]. PARTICUOLOGY,2009,7(3):220-224. |
| APA | Ren, Ying,Gao, Jian,Xu, Ji,Ge, Wei,&Li, Jinghai.(2009).Explicit solvent molecular dynamics simulations of chaperonin-assisted rhodanese folding.PARTICUOLOGY,7(3),220-224. |
| MLA | Ren, Ying,et al."Explicit solvent molecular dynamics simulations of chaperonin-assisted rhodanese folding".PARTICUOLOGY 7.3(2009):220-224. |
入库方式： OAI收割
来源：过程工程研究所
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