Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin
文献类型：期刊论文
| 作者 | Wei, Wei1,2; Ma, Guang-Hui1; Wang, Lian-Yan1; Wu, Jie1; Su, Zhi-Guo1 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2010 |
| 卷号 | 6期号:1页码:205-209 |
| 关键词 | Chitosan microspheres Insulin Oral administration |
| ISSN号 | 1742-7061 |
| 通讯作者 | Ma, GH |
| 英文摘要 | The delivery of insulin by non-parenteral routes has gained significant attention over the last two decades. In the present study, we prepared hollow quaternized chitosan microspheres by the SPG membrane emulsification technique and glutaraldehyde cross-linking method. The structural properties, as well as the uniform size and autofluorescence, enabled us to develop oral delivery of insulin which conserved the bioactivity of the encapsulated insulin, achieving bioadhesion of microspheres, increasing the loading ability and optimizing the release profile. In vivo evaluation also saw an optimal reduction in blood glucose level and powerful therapeutic effects after treatment with the designed microspheres, which further confirmed the feasibility of using hollow quaternized chitosan microspheres as insulin carriers for oral administration. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | DRUG-DELIVERY ; MEMBRANE EMULSIFICATION ; DIABETIC-RATS ; PROTEIN DRUG ; IN-VITRO ; NANOPARTICLES ; DEGRADATION ; HYDROGELS ; SYSTEMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273087900024 |
| 公开日期 | 2013-11-27 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6227]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Ma, Guang-Hui,Wang, Lian-Yan,et al. Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin[J]. ACTA BIOMATERIALIA,2010,6(1):205-209. |
| APA | Wei, Wei,Ma, Guang-Hui,Wang, Lian-Yan,Wu, Jie,&Su, Zhi-Guo.(2010).Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin.ACTA BIOMATERIALIA,6(1),205-209. |
| MLA | Wei, Wei,et al."Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin".ACTA BIOMATERIALIA 6.1(2010):205-209. |
入库方式： OAI收割
来源：过程工程研究所
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