Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique
文献类型：期刊论文
| 作者 | Lv, Pi-Ping1,2; Wei, Wei1; Gong, Fang-Ling1; Zhang, Yue-Ling1; Zhao, Hui-Ying2; Lei, Jian-Du1; Wang, Lian-Yan1; Ma, Guang-Hui1 |
| 刊名 | INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
 |
| 出版日期 | 2009-10-07 |
| 卷号 | 48期号:19页码:8819-8828 |
| 关键词 | SOLVENT EVAPORATION METHOD PLA MICROCAPSULES DELIVERY SYSTEM MICROSPHERES RELEASE INSULIN |
| ISSN号 | 0888-5885 |
| 通讯作者 | Wang, LY |
| 英文摘要 | Chitosan nanospheres have great potential in drug controlled release systems, because they show excellent degradability, biocompatibility, and nontoxicity. The particle size control and size distribution of nanospheres are necessary in order to improve reproducibility, bioavailability, and repeatable release behavior. In order to prepare uniformly sized and size-controllable chitosan nanospheres, in this study, a premix membrane emulsification technique was developed on the basis of direct membrane emulsification, and the uniformly sized chitosan nanospheres were successfully prepared by optimizing preparation conditions. The detail preparation process is as follows: The chitosan aqueous solution was used as a dispersed phase, and the mixture of liquid paraffin and petroleum ether containing emulsifier was used as a continuous phase. The coarse emulsions were first prepared by low-speed stator homogenization and then poured into the premix reservoir. Nanodroplets were achieved by extruding the coarse emulsions through the SPG (Shirasu porous glass) membrane with a high pressure. The nanodroplets were further cross-linked to obtain chitosan nanospheres. In this process, several factors played key roles in obtaining chitosan nanoparticles with narrow size distribution, including the amounts of emulsifier in oil phase, the composition of oil phase, the concentration of chitosan, the ratio of water to oil phase, the transmembrane pressure and number of passes, and so on. The results showed that the chitosan nanospheres from 300 nm to 1.85 mu m were successfully prepared by premix membrane emulsification by changing the pore size of the membrane and the polydispersity index could be as low as 0.027 under optimized conditions, and it is a potential technique to prepare size-controllable uniform chitosan nanospheres with fast production. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Chemical |
| 研究领域[WOS] | Engineering |
| 关键词[WOS] | SOLVENT EVAPORATION METHOD ; PLA MICROCAPSULES ; DELIVERY SYSTEM ; MICROSPHERES ; RELEASE ; INSULIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270362500006 |
| 公开日期 | 2013-11-29 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6567]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Beijing Inst Chem Technol, Sch Life Sci & Technol, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Pi-Ping,Wei, Wei,Gong, Fang-Ling,et al. Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2009,48(19):8819-8828. |
| APA | Lv, Pi-Ping.,Wei, Wei.,Gong, Fang-Ling.,Zhang, Yue-Ling.,Zhao, Hui-Ying.,...&Ma, Guang-Hui.(2009).Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,48(19),8819-8828. |
| MLA | Lv, Pi-Ping,et al."Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 48.19(2009):8819-8828. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。