Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum
文献类型：期刊论文
| 作者 | Tang, Ya-Jie1,2; Zhang, Wei1; Zhong, Jian-Jiang3 |
| 刊名 | BIORESOURCE TECHNOLOGY
 |
| 出版日期 | 2009-03-01 |
| 卷号 | 100期号:5页码:1852-1859 |
| 关键词 | Ganoderma lucidum pH-shift culture DOT-shift culture Fed-batch culture Integrated strategy |
| ISSN号 | 0960-8524 |
| 通讯作者 | Tang, YJ |
| 英文摘要 | Investigations on Ganoderma lucidum fermentation suggested that the responses of the cell growth and metabolites biosynthesis to pH and dissolved oxygen tension (DOT) were different. The ganoderic acid (GA) production of 321.6 mg/L was obtained in the pH-shift culture by combining a 4-day culture at pH 3.0 with the following 6-day culture at pH 4.5, which was higher by 45% and 300% compared with the culture at pH 3.0 and 4.5, respectively. The CA production of 487.1 mg/L was achieved in the DOT-shift culture by combining a 6-day culture at 25% of DOT with a following 6-day culture at 10% of DOT, which was higher by 43% and 230% compared with the culture at 25% and 10% of DOT, respectively. A fed-batch fermentation process by combining the above-mentioned pH-shift and DOT-shift strategies resulted in a significant synergistic enhancement of CA accumulation up to 754.6 mg/L, which is the highest reported in the submerged fermentation of G. lucidum in stirred-tank bioreactor. (C) 2008 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| 类目[WOS] | Agricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels |
| 研究领域[WOS] | Agriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels |
| 关键词[WOS] | EXOPOLYSACCHARIDE PRODUCTION ; SUBMERGED FERMENTATION ; CONTROL STRATEGY ; CULTURE PROCESS ; CULTIVATION ; HYPERPRODUCTION ; BIOREACTORS ; MYCELIA ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262704300024 |
| 公开日期 | 2013-12-10 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6706]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Hubei Univ Technol, Coll Bioengn, Hubei Prov Key Lab Ind Microbiol, Wuhan 430068, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China 3.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Minist Educ, Key Lab Microbial Metab, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Ya-Jie,Zhang, Wei,Zhong, Jian-Jiang. Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum[J]. BIORESOURCE TECHNOLOGY,2009,100(5):1852-1859. |
| APA | Tang, Ya-Jie,Zhang, Wei,&Zhong, Jian-Jiang.(2009).Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum.BIORESOURCE TECHNOLOGY,100(5),1852-1859. |
| MLA | Tang, Ya-Jie,et al."Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum".BIORESOURCE TECHNOLOGY 100.5(2009):1852-1859. |
入库方式： OAI收割
来源：过程工程研究所
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