BIOMINERALIZATION ON COPOLYMERIC MICROSPHERES SURFACE WITH DIFFERENT FUNCTIONAL GROUPS AND COMPOSITION
文献类型：期刊论文
| 作者 | Shi, Xu-dong1; Zhang, Yu2; Yu, Guo-qiang; Sun, Lei3; Gan, Zhi-hua1 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2012-10-20 |
| 期号 | 10页码:1157-1163 |
| 关键词 | Aliphatic polyester Microspheres Apatite Biomimetic mineralization method |
| ISSN号 | 1000-3304 |
| 其他题名 | Acta Polym. Sin. |
| 中文摘要 | PCL-b-PEG with different composition and functional groups were used to prepare microspheres with different surface properties by means of the double emulsion solvent evaporation method. Then, the biomineralization of microspheres was performed in the 1. 5 simulated body fluid (1. 5SBF). The effects of the hydrophilicity,, roughness and functional groups of microsphere surface on the formation of apatite were studied. It was found that the higher molar ratio of PEG to PCL leads to rougher and more hydrophilic microsphere surface, which results in the formation of more apatite. The functional groups were found to have great influence on the formation and distribution of apatite on the surface of microspheres. Apatite was distributed homogeneously on the surface of PCL20k-b-PEG(1k)-COOH microspheres. Moreover, the amount of apatite on microsphere surface increased with the mineralization time. The biomineralization had an initial period of ca. 4 days for apatite nucleation, followed by normal gradual growth. The results of this work indicate that the surface properties of microspheres such as hydrophilicity,, roughness and functional groups as well as the biomineralizaiton time could be used to control the apatite formation on microsphere surface. These results are expected to be used in the construction of tissue engineering scaffolds. |
| 英文摘要 | PCL-b-PEG with different composition and functional groups were used to prepare microspheres with different surface properties by means of the double emulsion solvent evaporation method. Then, the biomineralization of microspheres was performed in the 1. 5 simulated body fluid (1. 5SBF). The effects of the hydrophilicity,, roughness and functional groups of microsphere surface on the formation of apatite were studied. It was found that the higher molar ratio of PEG to PCL leads to rougher and more hydrophilic microsphere surface, which results in the formation of more apatite. The functional groups were found to have great influence on the formation and distribution of apatite on the surface of microspheres. Apatite was distributed homogeneously on the surface of PCL20k-b-PEG(1k)-COOH microspheres. Moreover, the amount of apatite on microsphere surface increased with the mineralization time. The biomineralization had an initial period of ca. 4 days for apatite nucleation, followed by normal gradual growth. The results of this work indicate that the surface properties of microspheres such as hydrophilicity,, roughness and functional groups as well as the biomineralizaiton time could be used to control the apatite formation on microsphere surface. These results are expected to be used in the construction of tissue engineering scaffolds. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 关键词[WOS] | IN-VITRO ; APATITE ; BIODEGRADATION ; POLYMERS ; OXIDE) |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000311586900013 |
| 公开日期 | 2013-11-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6273]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 3.Jishuitan Hosp, Beijing Inst Traumatol & Orthopaed, Beijing 100035, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Xu-dong,Zhang, Yu,Yu, Guo-qiang,et al. BIOMINERALIZATION ON COPOLYMERIC MICROSPHERES SURFACE WITH DIFFERENT FUNCTIONAL GROUPS AND COMPOSITION[J]. ACTA POLYMERICA SINICA,2012(10):1157-1163. |
| APA | Shi, Xu-dong,Zhang, Yu,Yu, Guo-qiang,Sun, Lei,&Gan, Zhi-hua.(2012).BIOMINERALIZATION ON COPOLYMERIC MICROSPHERES SURFACE WITH DIFFERENT FUNCTIONAL GROUPS AND COMPOSITION.ACTA POLYMERICA SINICA(10),1157-1163. |
| MLA | Shi, Xu-dong,et al."BIOMINERALIZATION ON COPOLYMERIC MICROSPHERES SURFACE WITH DIFFERENT FUNCTIONAL GROUPS AND COMPOSITION".ACTA POLYMERICA SINICA .10(2012):1157-1163. |
入库方式： OAI收割
来源：过程工程研究所
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