Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu
文献类型：期刊论文
| 作者 | Yang, Liangrong; Guo, Chen; Jia, Lianwei; Xie, Keng; Shou, Qinghui; Liu, Huizhou |
| 刊名 | INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
 |
| 出版日期 | 2010-09-15 |
| 卷号 | 49期号:18页码:8518-8525 |
| 关键词 | block-copolymers triblock copolymers delivery drug micellization chitosan gene nanostructures aggregation chemistry |
| ISSN号 | 0888-5885 |
| 其他题名 | Ind. Eng. Chem. Res. |
| 中文摘要 | A novel kind of biocompatible pH- and temperature-responsive magnetic nanoparticle consisting of iron oxide nanoparticles coated with pH-responsive chitosan oligosaccharide and temperature-responsive poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer was developed. The particles were characterized by TEM, DLS, VSM, FTIR spectroscopy, and TGA. The results indicated that the self-aggregation of the prepared nanoparticles was not only caused by the thermoinduced self-assembly of the immobilized block copolymers, but also affected by the pH-induced charge property change of the particle surface. The self-assembled behaviors can be readily reversed by adjusting the pH or temperature value. Thus, the attractive properties of reversible and controllable dual-responsive self-assembly might endow the biocompatible magnetic nanoparticles with potential applications in biomedical fields such as DNA delivery, drug targeting, and tissue engineering. |
| 英文摘要 | A novel kind of biocompatible pH- and temperature-responsive magnetic nanoparticle consisting of iron oxide nanoparticles coated with pH-responsive chitosan oligosaccharide and temperature-responsive poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer was developed. The particles were characterized by TEM, DLS, VSM, FTIR spectroscopy, and TGA. The results indicated that the self-aggregation of the prepared nanoparticles was not only caused by the thermoinduced self-assembly of the immobilized block copolymers, but also affected by the pH-induced charge property change of the particle surface. The self-assembled behaviors can be readily reversed by adjusting the pH or temperature value. Thus, the attractive properties of reversible and controllable dual-responsive self-assembly might endow the biocompatible magnetic nanoparticles with potential applications in biomedical fields such as DNA delivery, drug targeting, and tissue engineering. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Chemical |
| 研究领域[WOS] | Engineering |
| 关键词[WOS] | BLOCK-COPOLYMERS ; TRIBLOCK COPOLYMERS ; DELIVERY ; DRUG ; MICELLIZATION ; CHITOSAN ; GENE ; NANOSTRUCTURES ; AGGREGATION ; CHEMISTRY |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000281498300029 |
| 公开日期 | 2013-11-28 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/6334]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Liangrong,Guo, Chen,Jia, Lianwei,et al. Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2010,49(18):8518-8525. |
| APA | Yang, Liangrong,Guo, Chen,Jia, Lianwei,Xie, Keng,Shou, Qinghui,&Liu, Huizhou.(2010).Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,49(18),8518-8525. |
| MLA | Yang, Liangrong,et al."Fabrication of Biocompatible Temperature- and pH-Responsive Magnetic Nanoparticles and Their Reversible Agglomeration in Aqueous Milieu".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 49.18(2010):8518-8525. |
入库方式： OAI收割
来源：过程工程研究所
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