Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona
文献类型：期刊论文
| 作者 | Hu GQ(胡国庆) ; Jiao B(焦豹); Shi XH(施兴华); Valle RP; Fan QH; Zuo YY
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| 刊名 | ACS Nano
 |
| 出版日期 | 2013-12 |
| 卷号 | 7期号:12页码:10525-10533 |
| 通讯作者邮箱 | guoqing.hu@imech.ac.cn; yzuo@hawaii.edu |
| 关键词 | nanoparticle protein corona pulmonary surfactant molecular dynamics |
| ISSN号 | 1936-0851 |
| 产权排序 | [Hu, Guoqing; Jiao, Bao; Shi, Xinghua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China; [Valle, Russell P.; Fan, Qihui; Zuo, Yi Y.] Univ Hawaii Manoa, Dept Mech Engn, Honolulu, HI 96822 USA |
| 通讯作者 | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China |
| 合作状况 | 国际 |
| 中文摘要 | Interaction with the pulmonary surfactant film, being the first line of host defense, represents the initial bio-nano interaction in the lungs. Such interaction determines the fate of the inhaled nanoparticles and their potential therapeutic or toxicological effect. Despite considerable progress in optimizing physicochemical properties of nanoparticles for improved delivery and targeting, the mechanisms by which inhaled nanoparticles interact with the pulmonary surfactant film are still largely unknown. Here, using combined in vitro and in silico methods, we show how hydrophobicity and surface charge of nanoparticles differentially regulate the translocation and interaction with the pulmonary surfactant film. While hydrophilic nanoparticles generally translocate quickly across the pulmonary surfactant film, a significant portion of hydrophobic nanoparticles are trapped by the surfactant film and encapsulated in lipid protrusions upon film compression. Our results support a novel model of pulmonary surfactant lipoprotein corona associated with inhaled nanoparticles of different physicochemical properties. Our data suggest that the study of pulmonary nanotoxicology and nanoparticle-based pulmonary drug delivery should consider this lipoprotein corona. |
| 学科主题 | 交叉与边缘领域的力学 |
| 分类号 | 一类 |
| 收录类别 | SCI ; EI |
| 资助信息 | MOST [2011CB707604]; NSFC [11272321, 11272327]; NSF [CBET-1236596] |
| 原文出处 | http://pubs.acs.org/doi/pdf/10.1021/nn4054683 |
| 语种 | 英语 |
| WOS记录号 | WOS:000329137100011 |
| 公开日期 | 2014-01-17 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/47742]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hu GQ,Jiao B,Shi XH,et al. Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona[J]. ACS Nano,2013,7(12):10525-10533. |
| APA | Hu GQ,Jiao B,Shi XH,Valle RP,Fan QH,&Zuo YY.(2013).Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona.ACS Nano,7(12),10525-10533. |
| MLA | Hu GQ,et al."Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona".ACS Nano 7.12(2013):10525-10533. |
入库方式： OAI收割
来源：力学研究所
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