A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata
文献类型：期刊论文
| 作者 | Peng, Wen-Wen1,2; Zeng, Guang-Zhi1; Song, Wei-Wu1,2; Tan, Ning-Hua1 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 10期号:7页码:1317-1321 |
| 关键词 | Clausena excavata Carbazole alkaloids Alkaloids Excavatines A-C Cytotoxic activity |
| ISSN号 | 1612-1872 |
| 通讯作者 | Zeng,GZ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.,gzh_zeng@mail.kib.ac.cn ; nhtan@mail.kib.ac.cn |
| 英文摘要 | One new carbazole alkaloid, excavatine A (1), and two additional new alkaloids, excavatine B (2) and excavatine C (3), were isolated from the stems and leaves of Clausena excavataBurm.f. (Rutaceae). Their structures were determined on the basis of detailed spectroscopic analyses, especially 2D-NMR and HR-EI-MS data. Compounds 1-3 were tested for their cytotoxic activities against A549, HeLa, and BGC-823 cancer cell lines, and for their antimicrobial activities against Candida albicans and Staphylococcus aureus. Only 1 exhibited cytotoxicity against A549 and HeLa cell lines with the IC50 values of 5.25 and 1.91g/ml, respectively. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | O-TERPENOIDAL COUMARINS |
| 收录类别 | SCI |
| 资助信息 | National New Drug Innovation Major Project of China [2011ZX09307-002-02];National Natural Science Foundation of China [U1032602, 91013002, 30725048, 201102152];National Basic Research Program of China [2009CB522300, 2013CB127505];Chinese Academy of Sciences;Natural Science Foundation of Yunnan Province [2012GA003] |
| 语种 | 英语 |
| WOS记录号 | WOS:000327697400014 |
| 公开日期 | 2014-01-13 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17406]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Wen-Wen,Zeng, Guang-Zhi,Song, Wei-Wu,et al. A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata[J]. CHEMISTRY & BIODIVERSITY,2013,10(7):1317-1321. |
| APA | Peng, Wen-Wen,Zeng, Guang-Zhi,Song, Wei-Wu,&Tan, Ning-Hua.(2013).A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata.CHEMISTRY & BIODIVERSITY,10(7),1317-1321. |
| MLA | Peng, Wen-Wen,et al."A New Cytotoxic Carbazole Alkaloid and Two New Other Alkaloids from Clausena excavata".CHEMISTRY & BIODIVERSITY 10.7(2013):1317-1321. |
入库方式： OAI收割
来源：昆明植物研究所
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