Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum
文献类型：期刊论文
| 作者 | Yan, Yong-Ming1,3; Ai, Jun2; Zhou, Li-Li2; Chung, Arthur C. K.4; Li, Rong4 ; Nie, Jing2; Fang, Ping1; Wang, Xin-Long1; Luo, Jie1; Hu, Qun1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 15期号:21页码:5488-5491 |
| ISSN号 | 1523-7060 |
| 关键词 | DIABETIC-NEPHROPATHY HIGH-GLUCOSE MESANGIAL CELLS UP-REGULATION EXPRESSION ACTIVATION PATHWAYS |
| 通讯作者 | Hou,FF (reprint author),Southern Med Univ,Nanfang Hosp,Educ Minist,Div Nephrol,Key Lab Organ Failure Res,Guangzhou 510515,Guangdong,Peoples R China.,ffhouguangzhou@163.com ; yxcheng@mail.kib.ac.cn |
| 英文摘要 | (+)-Lingzhiol and (-)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic of sharing a C-3'-C-7' axis. Biological evaluation showed that (+)-lingzhiol or ()-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-beta 1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions. |
| 学科主题 | Chemistry |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | DIABETIC-NEPHROPATHY ; HIGH-GLUCOSE ; MESANGIAL CELLS ; UP-REGULATION ; EXPRESSION ; ACTIVATION ; PATHWAYS |
| 资助信息 | NSFC-Joint Foundation of Yunnan Province [U1202222];State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P2013-ZZ03];Research Grant Council of Hong Kong [GRF 463612] |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000326615100024 |
| 公开日期 | 2014-01-13 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17415]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Educ Minist, Div Nephrol,Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Yong-Ming,Ai, Jun,Zhou, Li-Li,et al. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum[J]. ORGANIC LETTERS,2013,15(21):5488-5491. |
| APA | Yan, Yong-Ming.,Ai, Jun.,Zhou, Li-Li.,Chung, Arthur C. K..,Li, Rong.,...&Cheng, Yong-Xian.(2013).Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum.ORGANIC LETTERS,15(21),5488-5491. |
| MLA | Yan, Yong-Ming,et al."Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum".ORGANIC LETTERS 15.21(2013):5488-5491. |
入库方式： OAI收割
来源：昆明植物研究所
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