Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense
文献类型：期刊论文
| 作者 | Zhao, Da-Ke1; Ai, Hong-Lian2; Zi, Shu-Hui2; Zhang, Li-Mei2; Yang, Sheng-Chao2; Guo, Hua-Chun2; Shen, Yong2; Chen, Yan-Ping2; Chen, Ji-Jun3
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| 刊名 | FITOTERAPIA
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| 出版日期 | 2013-12-01 |
| 卷号 | 91页码:280-283 |
| 关键词 | Diterpenoid alkaloids Weisaconitines A-D Analgesic activity Aconitum weixiense Ranunculaceae |
| ISSN号 | 0367-326X |
| 通讯作者 | Shen,Y (reprint author),Yunnan Agr Univ,Coll Agr & Biotechnol,Kunming 650201,Peoples R China.,pharmsy@sina.com ; chenjj@mail.kib.ac.cn |
| 英文摘要 | Four new C-18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 资助信息 | State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS [P2012-KF04];National Natural Science Foundation of China [21362045];project of Sciences and Technology Department of Yunnan Province [2012CG007] |
| 语种 | 英语 |
| WOS记录号 | WOS:000327574300040 |
| 公开日期 | 2014-01-13 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17419]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Agr, Kunming 650091, Peoples R China 2.Yunnan Agr Univ, Coll Agr & Biotechnol, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Da-Ke,Ai, Hong-Lian,Zi, Shu-Hui,et al. Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense[J]. FITOTERAPIA,2013,91:280-283. |
| APA | Zhao, Da-Ke.,Ai, Hong-Lian.,Zi, Shu-Hui.,Zhang, Li-Mei.,Yang, Sheng-Chao.,...&Chen, Ji-Jun.(2013).Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense.FITOTERAPIA,91,280-283. |
| MLA | Zhao, Da-Ke,et al."Four new C-18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense".FITOTERAPIA 91(2013):280-283. |
入库方式： OAI收割
来源：昆明植物研究所
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