Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles
文献类型：期刊论文
| 作者 | Wang GW(王刚伟)1; Zhou AX(周安西)1; Wang JJ(王君姣)1; Hu RB(胡荣斌)1; Yang SD(杨尚东)1,2 |
| 刊名 | Organic Letters
 |
| 出版日期 | 2013 |
| 卷号 | 15期号:20页码:5270-5273 |
| ISSN号 | 1523-7060 |
| 通讯作者 | 杨尚东 |
| 英文摘要 | The first Pd(II)-catalyzed C-H addition to isatins by direct sp2/sp3 C-H bond activation for the construction of 3-substituted-3-hydroxy-2-oxindoles is reported. The bidentate nitrogen ligands were found to promote this reaction. Specifically, the preliminary bioassay indicated that 3-(5-chlorobenzoxazole)-3-hydroxy-N-benzyl-2-oxindole (2w) is a new inhibitor of human kidney cancer and hepatocellular carcinoma cells. Moreover, this reaction system exhibits great functional group tolerance and requires no directing group, extra base, or additives. |
| 学科主题 | 物理化学与绿色催化 |
| 收录类别 | SCI |
| 资助信息 | the NSFC (Nos. 21072079;21272100);Program for New Century Excellent Talents in University (NCET-11-0215) |
| 语种 | 英语 |
| WOS记录号 | WOS:000326121700032 |
| 公开日期 | 2013-12-30 |
| 源URL | [http://210.77.64.217/handle/362003/4953]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 |
| 作者单位 | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang GW,Zhou AX,Wang JJ,et al. Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles[J]. Organic Letters,2013,15(20):5270-5273. |
| APA | Wang GW,Zhou AX,Wang JJ,Hu RB,&Yang SD.(2013).Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles.Organic Letters,15(20),5270-5273. |
| MLA | Wang GW,et al."Palladium-Catalyzed sp(2) and sp(3) C-H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles".Organic Letters 15.20(2013):5270-5273. |
入库方式： OAI收割
来源：兰州化学物理研究所
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