A hand-over-hand diffusing model for myosin-VI molecular motors
文献类型：期刊论文
| 作者 | Xie, P ; Dou, SX ; Wang, PY |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2006 |
| 卷号 | 122期号:2页码:90 |
| 关键词 | ACTIN-BASED MOTOR LARGE STEP-SIZE STRUCTURAL DYNAMICS MUSCLE-CONTRACTION DOMAIN DETERMINES CELL-MIGRATION LEVER ARM MECHANISM ACTOMYOSIN MOVEMENT |
| ISSN号 | 0301-4622 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Lab Soft Matter Phys, Beijing Natl Lab Condensed Matter Phys, Inst Phys, Beijing 100080, Peoples R China. |
| 中文摘要 | Single molecules of dimeric myosin-VI have been demonstrated to be able to move processively towards the pointed end of actin filament with a mean step size of similar to 36 mn. Here we present a hand-over-hand diffusing mechanism for this unidirectional movement. Based on this mechanism, its dynamical behaviors such as the step-size distribution, dwell-time distributions and mean dwell time at various ATP and ADP concentrations and under various loads are studied in detail. The calculated results show good agreement with previous experimental results. The processive movement of mutant myosin-V with its neck domains truncated to only one IQ motif can also be explained by using this hand-over-hand diffusing model. (c) 2006 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/32926]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P,Dou, SX,Wang, PY. A hand-over-hand diffusing model for myosin-VI molecular motors[J]. BIOPHYSICAL CHEMISTRY,2006,122(2):90. |
| APA | Xie, P,Dou, SX,&Wang, PY.(2006).A hand-over-hand diffusing model for myosin-VI molecular motors.BIOPHYSICAL CHEMISTRY,122(2),90. |
| MLA | Xie, P,et al."A hand-over-hand diffusing model for myosin-VI molecular motors".BIOPHYSICAL CHEMISTRY 122.2(2006):90. |
入库方式： OAI收割
来源：物理研究所
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