A model for processive movement of single-headed myosin-IX
文献类型：期刊论文
| 作者 | Xie, P |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 151期号:1-2页码:71 |
| 关键词 | LEVER-ARM MODEL HAND-OVER-HAND MOLECULAR MOTORS FORCE-GENERATION V PROCESSIVITY STRUCTURAL DYNAMICS KINESIN MOTORS ATP HYDROLYSIS MECHANISM ACTIN |
| ISSN号 | 0301-4622 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Inst Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | It is puzzling that in spite of its single-headed structure, myosin-IX can move processively along actin. Here, based on the experimental evidence that the strong binding of myosin to actin in rigor state induces structural changes to several local actin monomers, a Brownian ratchet model is proposed to describe this processive movement. In the model, the actin plays an active role in the motility of single-headed myosin, in contrast to the common belief that the actin acts only as a passive track for the motility of the myosin. The unidirectional movement is due to both the asymmetric periodic potential of the myosin interacting with actin and the forward Stokes force induced by the relative rotation of the neck domain to the motor domain, while the processivity is determined by the binding affinity of the myosin for actin in ATP state. This gives a good explanation to the high processivity of myosin-IX, which results from its high binding affinity for actin in ATP state due to the presence of unique loop 2 insertion or N-terminal extension. The experimental results on the motility of myosin-IX such as the step size, large forward/backward stepping ratio, run length, stall force, etc, are explained well. (C) 2010 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/32987]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P. A model for processive movement of single-headed myosin-IX[J]. BIOPHYSICAL CHEMISTRY,2010,151(1-2):71. |
| APA | Xie, P.(2010).A model for processive movement of single-headed myosin-IX.BIOPHYSICAL CHEMISTRY,151(1-2),71. |
| MLA | Xie, P."A model for processive movement of single-headed myosin-IX".BIOPHYSICAL CHEMISTRY 151.1-2(2010):71. |
入库方式： OAI收割
来源：物理研究所
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