A model for the dynamics of mammalian family X DNA polymerases
文献类型：期刊论文
| 作者 | Xie, P |
| 刊名 | JOURNAL OF THEORETICAL BIOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 277期号:1页码:111 |
| 关键词 | BASE-EXCISION-REPAIR MU POL-MU CRYSTAL-STRUCTURES TERMINAL DEOXYNUCLEOTIDYLTRANSFERASE V(D)J RECOMBINATION EXONUCLEASE SITES BETA LAMBDA MECHANISM REPLICATION |
| ISSN号 | 0022-5193 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Inst Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | Based on available structural studies, a model is presented for polymerization dynamics of mammalian family X DNA polymerases, including polymerases b, lambda, mu, and terminal deoxynucleotidyl transferase (TdT). Using the model, distinct polymerization activities and processivities of the four polymerases acting on different forms of DNA substrate are analyzed and studied theoretically. A "gradient" of template dependence of polymerases b, lambda, mu, and TdT is well explained. The much higher occurrence frequencies of the -1 frameshift DNA synthesis by pols lambda and mu than that by pol beta are well explained. The theoretical results on the polymerization processivities are also in agreement with the available experimental data. (C) 2011 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [10974248] |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/32989]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P. A model for the dynamics of mammalian family X DNA polymerases[J]. JOURNAL OF THEORETICAL BIOLOGY,2011,277(1):111. |
| APA | Xie, P.(2011).A model for the dynamics of mammalian family X DNA polymerases.JOURNAL OF THEORETICAL BIOLOGY,277(1),111. |
| MLA | Xie, P."A model for the dynamics of mammalian family X DNA polymerases".JOURNAL OF THEORETICAL BIOLOGY 277.1(2011):111. |
入库方式： OAI收割
来源：物理研究所
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