A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases
文献类型：期刊论文
| 作者 | Xie, P |
| 刊名 | THEORETICAL BIOLOGY AND MEDICAL MODELLING
 |
| 出版日期 | 2011 |
| 卷号 | 8 |
| 关键词 | SYN THYMINE DIMER I KLENOW FRAGMENT SULFOLOBUS-SOLFATARICUS ERROR-PRONE LESION-BYPASS CRYSTAL-STRUCTURE TRANSLESION REPLICATION CONFORMATIONAL-CHANGES REVERSE-TRANSCRIPTASE STRUCTURAL INSIGHTS |
| ISSN号 | 1742-4682 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Key Lab Soft Matter Phys, Inst Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | Y-family DNA polymerases are characterized by low-fidelity synthesis on undamaged DNA and ability to catalyze translesion synthesis over the damaged DNA. Their translocation along the DNA template is an important event during processive DNA synthesis. In this work we present a Brownian ratchet model for this translocation, where the directed translocation is rectified by the nucleotide binding to the polymerase. Using the model, different features of the available structures for Dpo4, Dbh and polymerase. in binary and ternary forms can be easily explained. Other dynamic properties of the Y-family polymerases such as the fast translocation event upon dNTP binding for Dpo4 and the considerable variations of the processivity among the polymerases can also be well explained by using the model. In addition, some predicted results of the DNA synthesis rate versus the external force acting on Dpo4 and Dbh polymerases are presented. Moreover, we compare the effect of the external force on the DNA synthesis rate of the Y-family polymerase with that of the replicative DNA polymerase. |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [10974248] |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/33152]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P. A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases[J]. THEORETICAL BIOLOGY AND MEDICAL MODELLING,2011,8. |
| APA | Xie, P.(2011).A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases.THEORETICAL BIOLOGY AND MEDICAL MODELLING,8. |
| MLA | Xie, P."A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases".THEORETICAL BIOLOGY AND MEDICAL MODELLING 8(2011). |
入库方式： OAI收割
来源：物理研究所
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