A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells
文献类型：期刊论文
| 作者 | Au, L ; Zheng, DS ; Zhou, F ; Li, ZY ; Li, XD ; Xia, YN |
| 刊名 | ACS NANO
 |
| 出版日期 | 2008 |
| 卷号 | 2期号:8页码:1645 |
| 关键词 | SHAPE-CONTROLLED SYNTHESIS OPTICAL-PROPERTIES BIOMEDICAL APPLICATIONS MONOCLONAL-ANTIBODIES PLASMONIC PROPERTIES METAL NANOPARTICLES CONTRAST AGENTS NANOSTRUCTURES THERAPY NANOSHELLS |
| ISSN号 | 1936-0851 |
| 通讯作者 | Xia, YN: Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA. |
| 中文摘要 | Gold nanocages with an average edge length of 65 +/- 7 nm and a strong absorption peak at 800 nm were conjugated with monoclonal antibodies (anti-HER2) to target breast cancer cells (SK-BR-3) through the epidermal growth factor receptor (in this case, HER2), which is overexpressed on the surfaces of the cells. Both the number of immuno Au nano(ages immobilized per cell and the photothermal therapeutic effect were quantified using flow cytometry. The targeted cells were irradiated with a pulsed near-infrared laser, and by varying the power density, the duration of laser exposure, and the time of response after irradiation, we were able to optimize the treatment conditions to achieve effective destruction of the cancer cells. We found that cells targeted with the immuno Au nanocages responded immediately to laser irradiation and that the cellular damage was irreversible at power densities greater than 1.6 W/cm(2). The percentage of dead cells increased with increasing exposure time up to 5 min and then became steady. By quantifying the photothermal effect of immuno Au nanocages, critical information with regards to both the optimal dosage of nanocages and parameters of the laser irradiation has been garnered and will be applied to future in vivo studies. |
| 收录类别 | SCI |
| 资助信息 | NIH [1DPOD000798, R01 CA120480]; NSF Career Award; UW; NSF and NCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/33188]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Au, L,Zheng, DS,Zhou, F,et al. A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells[J]. ACS NANO,2008,2(8):1645. |
| APA | Au, L,Zheng, DS,Zhou, F,Li, ZY,Li, XD,&Xia, YN.(2008).A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells.ACS NANO,2(8),1645. |
| MLA | Au, L,et al."A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells".ACS NANO 2.8(2008):1645. |
入库方式： OAI收割
来源：物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。