Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes
文献类型：期刊论文
| 作者 | Duan, ZW ; Li, W ; Xie, P ; Dou, SX ; Wang, PY |
| 刊名 | CHINESE PHYSICS B
 |
| 出版日期 | 2010 |
| 卷号 | 19期号:4 |
| 关键词 | FISSION YEAST EPIGENETIC INHERITANCE UBIQUITINATION METHYLATION H2B H3 CHROMOSOME CHROMATIN PARTICLE RAD6 |
| ISSN号 | 1674-1056 |
| 通讯作者 | Wang, PY: Chinese Acad Sci, Inst Phys, Key Lab Soft Matter Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | Using Brownian dynamics simulation, we studied the effect of histone modifications on conformations of an array of nucleosomes in a segment of chromatin. The simulation demonstrated that the segment of chromatin shows the dynamic behaviour that its conformation can switch between a state with nearly all of the histones being wrapped by DNA and a state with nearly all of the histones being unwrapped by DNA, thus involving the "cross-talking" interactions among the histones. Each state can stay for a sufficiently long time. These conformational states are essential for gene expression or gene silence. The simulation also shows that these conformational states can be inherited by the daughter DNAs during DNA replication, giving a theoretical explanation of the epigenetic phenomenon. |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [10834014, 10674173]; National Basic Research Program of China [2009CB930704] |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/34356]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Duan, ZW,Li, W,Xie, P,et al. Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes[J]. CHINESE PHYSICS B,2010,19(4). |
| APA | Duan, ZW,Li, W,Xie, P,Dou, SX,&Wang, PY.(2010).Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes.CHINESE PHYSICS B,19(4). |
| MLA | Duan, ZW,et al."Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes".CHINESE PHYSICS B 19.4(2010). |
入库方式： OAI收割
来源：物理研究所
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