Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy
文献类型：期刊论文
| 作者 | Meng, J ; Duan, JH ; Kong, H ; Li, L ; Wang, C ; Xie, SS ; Chen, SC ; Gu, N ; Xu, HY ; Yang, XD |
| 刊名 | SMALL
 |
| 出版日期 | 2008 |
| 卷号 | 4期号:9页码:1364 |
| 关键词 | RENAL-CELL CANCER DENDRITIC CELLS RANDOMIZED-TRIAL MAMMALIAN-CELLS GENE DELIVERY PLASMID DNA VACCINE MELANOMA TRANSPORTERS RESPONSES |
| ISSN号 | 1613-6810 |
| 通讯作者 | Xu, HY: Chinese Acad Med Sci, Dept Biomed Engn, Inst Basic Med Sci, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China. |
| 中文摘要 | The biomedical applications of carbon nanotubes (CNTs) have attracted deep interest in recent years. Antitumor immunotherapy has the potential to improve the prognosis of cancer treatment but the efficacy of current immunotherapy generally needs further improvement. Multi-walled CNTs conjugated to tumor lysate protein tire investigated as to whether they would enhance the efficacy of an immunotherapy employing a tumor-cell vaccine in a mouse model bearing the H22 liver cancer. The tumor cure rate is found to be markedly improved by CNTs conjugated to tumor lysate protein. The cellular antitumor immune reaction is also enhanced. Moreover, the observed antitumor immune response is relatively specific against the tumor intended for treatment. These findings suggest that CNTs may have a prospective role in the development of new antitumor immunotherapies. |
| 收录类别 | SCI |
| 资助信息 | Natural Science Foundation of China [90306004, 90406024]; National Center of Nanoscience and Technology of China; National Key Scientific Projects of China [2006CB933204]; Natural Science Foundation of Beijing [Z0005190043511] |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/34477]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Meng, J,Duan, JH,Kong, H,et al. Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy[J]. SMALL,2008,4(9):1364. |
| APA | Meng, J.,Duan, JH.,Kong, H.,Li, L.,Wang, C.,...&Yang, XD.(2008).Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy.SMALL,4(9),1364. |
| MLA | Meng, J,et al."Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy".SMALL 4.9(2008):1364. |
入库方式： OAI收割
来源：物理研究所
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