Dynamic simulation of the effect of calcium-release activated calcium channel on cytoplasmic Ca(2+) oscillation
文献类型：期刊论文
| 作者 | Chen, XF ; Li, CX ; Wang, PY ; Li, M ; Wang, WC |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 136期号:2-3页码:87 |
| 关键词 | PLASMA-MEMBRANE CRAC CHANNEL ENDOPLASMIC-RETICULUM CAPACITATIVE CA2+ STORE DEPLETION POOL MODEL I-CRAC ENTRY STIM1 RECEPTOR |
| ISSN号 | 0301-4622 |
| 通讯作者 | Wang, WC: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, POB 603, Beijing 100080, Peoples R China. |
| 中文摘要 | A mathematical model is proposed to illustrate the activation of STIM1 (stromal interaction molecule 1) protein, the assembly and activation of calcium-release activated calcium (CRAC) channels in T cells. In combination with De Young-Keizer-Li-Rinzel model, we successfully reproduce a sustained Ca(2+) oscillation in cytoplasm. Our results reveal that Ca(2+) Oscillation dynamics in cytoplasm can be significantly affected by the way how the Orail CRAC channel are assembled and activated. A low sustained Ca(2+) influx is observed through the CRAC channels across the plasma membrane. In particular, our model shows that a tetrameric channel complex can effectively regulate the total quantity of the channels and the ratio of the active channels to the total channels, and a period of Ca(2+) oscillation about 29 s is in agreement with published experimental data. The bifurcation analyses illustrate the different dynamic properties between our mixed Ca(2+) feedback model and the single positive or negative feedback models. (c) 2008 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/36260]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen, XF,Li, CX,Wang, PY,et al. Dynamic simulation of the effect of calcium-release activated calcium channel on cytoplasmic Ca(2+) oscillation[J]. BIOPHYSICAL CHEMISTRY,2008,136(2-3):87. |
| APA | Chen, XF,Li, CX,Wang, PY,Li, M,&Wang, WC.(2008).Dynamic simulation of the effect of calcium-release activated calcium channel on cytoplasmic Ca(2+) oscillation.BIOPHYSICAL CHEMISTRY,136(2-3),87. |
| MLA | Chen, XF,et al."Dynamic simulation of the effect of calcium-release activated calcium channel on cytoplasmic Ca(2+) oscillation".BIOPHYSICAL CHEMISTRY 136.2-3(2008):87. |
入库方式： OAI收割
来源：物理研究所
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