Dynamics of backtracking long pauses of RNA polymerase
文献类型：期刊论文
| 作者 | Xie, P |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
 |
| 出版日期 | 2009 |
| 卷号 | 1789期号:3页码:212 |
| 关键词 | 3.3 ANGSTROM RESOLUTION STRUCTURAL BASIS TRANSCRIPTION ELONGATION ESCHERICHIA-COLI CRYSTAL-STRUCTURE MODEL DNA TERMINATION MECHANISM FORCE |
| ISSN号 | 1874-9399 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Inst Phys, Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | The dynamics of backtracking long pauses by RNA polymerase is quantitatively studied based on our proposed model. Analytical formulas are obtained for the dependence of mean backtracking time and mean lifetime of backtracking long pauses on the binding affinity V(0) of RNAP to the DNA and RNA lattices, an important parameter for the transcription elongation complex. By comparison of the theoretically with experimentally obtained mean backtracking times, the value of binding affinity V(0) is predicted. Using the predicted V(0), the effects of external load on the mean backtracking time, on the lifetime of the backtracking long pauses and on the exit from the backtracking long pauses are studied. The results are in agreement with the available experimental data and, moreover, some predicted results are presented. In addition, using this V(0) we study the processivity of RNA polymerase under no and sideways forces. (C) 2008 Elsevier B.V. All rights reserved |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/36294]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P. Dynamics of backtracking long pauses of RNA polymerase[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,2009,1789(3):212. |
| APA | Xie, P.(2009).Dynamics of backtracking long pauses of RNA polymerase.BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS,1789(3),212. |
| MLA | Xie, P."Dynamics of backtracking long pauses of RNA polymerase".BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1789.3(2009):212. |
入库方式： OAI收割
来源：物理研究所
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