Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells
文献类型：期刊论文
| 作者 | Li, CX ; Chen, XF ; Wang, PY ; Wang, WC |
| 刊名 | CHINESE PHYSICS LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 27期号:2 |
| 关键词 | ACTIVATED CALCIUM-CHANNEL OSCILLATIONS MODEL SENSOR STORE STIM1 |
| ISSN号 | 0256-307X |
| 通讯作者 | Wang, WC: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | A reaction-diffusion model is built to investigate the temporal and spatial patterns of cytoplasmic Ca2+ dynamics under the effects of Ca2+-release activated Ca2+ (CRAC) channels in T cells. Simulation results show a strong dependence of the modulation mode of Ca2+ oscillation and dynamic patterns of Ca2+ wave on the influx rate through the CRAC channel (k(soc)). When k(soc) is small, cytoplasmic Ca2+ is modulated as a frequency-modulation (FM) signal, whereas it shows an amplitude modulation (AM) mode after k(soc) passes through a critical value. The heterogeneity in spatial Ca2+ distribution is mostly arising from the influx through CRAC channels in both FM and AM modes. During each Ca2+ spike, a more sustained cytoplasmic Ca2+ gradient is maintained in the AM mode rather than in the FM mode. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/36687]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, CX,Chen, XF,Wang, PY,et al. Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells[J]. CHINESE PHYSICS LETTERS,2010,27(2). |
| APA | Li, CX,Chen, XF,Wang, PY,&Wang, WC.(2010).Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells.CHINESE PHYSICS LETTERS,27(2). |
| MLA | Li, CX,et al."Effects of CRAC Channel on Spatiotemporal Ca2+ Patterns in T Cells".CHINESE PHYSICS LETTERS 27.2(2010). |
入库方式： OAI收割
来源：物理研究所
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