Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin
文献类型：期刊论文
| 作者 | Li, W ; Sun, ZQ ; Xie, P ; Dou, SX ; Wang, WC ; Wang, PY |
| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2012 |
| 卷号 | 85期号:2 |
| 关键词 | INTERSTRAND CROSS-LINKS PURINE-BASES MONOFUNCTIONAL ADDUCTS SEQUENCE SPECIFICITY FORCE SPECTROSCOPY ESCHERICHIA-COLI DUPLEX DNA TRANS-DIAMMINEDICHLOROPLATINUM(II) BINDING AGENTS |
| ISSN号 | 1539-3755 |
| 通讯作者 | Li, W: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | Magnetic tweezers were employed to investigate the interactions between DNA and cisplatin (transplatin). Cisplatin shortened DNA and reduced its persistence length more significantly than transplatin due to the formation of many more diadducts than those formed by transplatin. Interestingly, the presence of transplatin could enhance the ability of cisplatin in shortening DNA. An optimal concentration ratio of transplatin to cisplatin existed at which cisplatin showed the highest ability in shortening DNA. Moreover, abrupt length changes were also observed when DNA was treated with a mixture of cisplatin and transplatin at high concentrations. A model was proposed to qualitatively explain well these results. |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [10834014, 11104341]; National Basic Research Program of China (973 Program) [2009CB930704] |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/36893]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, W,Sun, ZQ,Xie, P,et al. Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin[J]. PHYSICAL REVIEW E,2012,85(2). |
| APA | Li, W,Sun, ZQ,Xie, P,Dou, SX,Wang, WC,&Wang, PY.(2012).Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin.PHYSICAL REVIEW E,85(2). |
| MLA | Li, W,et al."Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin".PHYSICAL REVIEW E 85.2(2012). |
入库方式： OAI收割
来源：物理研究所
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