Growing behavior of endothelial cells on electrospun aligned nanofibrous film of polyurethane
文献类型：期刊论文
| 作者 | Han, ZZ ; Kong, H ; Meng, J ; Wang, CY ; Zhu, GJ ; Xie, SS ; Xu, HY |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:5页码:1070 |
| 关键词 | NANOSCALE TOPOGRAPHY EXTRACELLULAR-MATRIX BASEMENT-MEMBRANE SCAFFOLD PROLIFERATION |
| ISSN号 | 0251-0790 |
| 通讯作者 | Xu, HY: Chinese Acad Med Sci, Dept Biomed Engn, Beijing 100005, Peoples R China. |
| 中文摘要 | The nanofibrous film of polyurethane (PU) with aligned topography was fabricated by electrospinning for human umbilical vein endothelial cells(HUVEC) growth. The morphology of nanofibrous film was observed and characterized by scanning electron microscopy(SEM). The cells growth behavior including proliferation, cytoskeleton formation of actin, tublin and vinculin, and tissue factor(TF) release was investigated via cell viability assay, confocal observation and TF assay. The average diameter of the generated fiber was around 300-500 nm. The experimental results indicate that the aligned nanofibrous film of PU exhibited promotional influence on the cell proliferation. It was also observed that the film possessed an advantage of supporting HUVEC migrating and aggregating along the axis of the aligned nanofibers, which is one of the important functions in the process of endothelium regeneration. It was also demonstrated that the endothelial cells growing on the film expressed non-thrombogenic phenotype with low tissue factor released. These results indicate the favorable interactions between ECs and the film, implying that the aligned nanofibrous film of PU has a promising potential for vascular engineering. |
| 收录类别 | SCI |
| 语种 | 中文 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/38864]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Han, ZZ,Kong, H,Meng, J,et al. Growing behavior of endothelial cells on electrospun aligned nanofibrous film of polyurethane[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(5):1070. |
| APA | Han, ZZ.,Kong, H.,Meng, J.,Wang, CY.,Zhu, GJ.,...&Xu, HY.(2008).Growing behavior of endothelial cells on electrospun aligned nanofibrous film of polyurethane.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(5),1070. |
| MLA | Han, ZZ,et al."Growing behavior of endothelial cells on electrospun aligned nanofibrous film of polyurethane".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.5(2008):1070. |
入库方式： OAI收割
来源：物理研究所
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