Human brain cancer studied by resonance Raman spectroscopy
文献类型：期刊论文
| 作者 | Zhou, Y ; Liu, CH ; Sun, Y ; Pu, Y ; Boydston-White, S ; Liu, YL ; Alfano, RR |
| 刊名 | JOURNAL OF BIOMEDICAL OPTICS
 |
| 出版日期 | 2012 |
| 卷号 | 17期号:11 |
| 关键词 | PITUITARY-ADENOMAS HUMAN TISSUES HUMAN-BREAST IN-VIVO FT-IR TUMORS FLUORESCENCE MICROSPECTROSCOPY SPECTRA IV |
| ISSN号 | 1083-3668 |
| 通讯作者 | Liu, CH: CUNY City Coll, Inst Ultrafast Spect & Lasers, Dept Phys, New York, NY 10031 USA. |
| 中文摘要 | The resonance Raman (RR) spectra of six types of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro. Forty-three RR spectra from seven subjects are investigated. The spectral peaks from malignant meningioma, stage III (cancer), benign meningioma (benign), normal meningeal tissues (normal), glioblastoma multiforme grade IV (cancer), acoustic neuroma (benign), and pituitary adenoma (benign) are analyzed. Using a 532-nm excitation, the resonance-enhanced peak at 1548 cm(-1) (amide II) is observed in all of the tissue specimens, but is not observed in the spectra collected using the nonresonance Raman system. An increase in the intensity ratio of 1587 to 1605 cm(-1) is observed in the RR spectra collected from meningeal cancer tissue as compared with the spectra collected from the benign and normal meningeal tissue. The peak around 1732 cm(-1) attributed to fatty acids (lipids) are diminished in the spectra collected from the meningeal cancer tumors as compared with the spectra from normal and benign tissues. The characteristic band of spectral peaks observed between 2800 and 3100 cm(-1) are attributed to the vibrations of methyl (-CH3) and methylene (-CH2-) groups. The ratio of the intensities of the spectral peaks of 2935 to 2880 cm(-1) from the meningeal cancer tissues is found to be lower in comparison with that of the spectral peaks from normal, and benign tissues, which may be used as a distinct marker for distinguishing cancerous tissues from normal meningeal tissues. The statistical methods of principal component analysis and the support vector machine are used to analyze the RR spectral data collected from meningeal tissues, yielding a diagnostic sensitivity of 90.9% and specificity of 100% when two principal components are used. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.11.116021] |
| 收录类别 | SCI |
| 资助信息 | General Hospital of the Air Force, China; U.S. Army Medical Research and Material Command (USAMRMC) [81XWH-11-1-0335, 47204-00-1] |
| 语种 | 英语 |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/39519]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhou, Y,Liu, CH,Sun, Y,et al. Human brain cancer studied by resonance Raman spectroscopy[J]. JOURNAL OF BIOMEDICAL OPTICS,2012,17(11). |
| APA | Zhou, Y.,Liu, CH.,Sun, Y.,Pu, Y.,Boydston-White, S.,...&Alfano, RR.(2012).Human brain cancer studied by resonance Raman spectroscopy.JOURNAL OF BIOMEDICAL OPTICS,17(11). |
| MLA | Zhou, Y,et al."Human brain cancer studied by resonance Raman spectroscopy".JOURNAL OF BIOMEDICAL OPTICS 17.11(2012). |
入库方式： OAI收割
来源：物理研究所
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