Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells
文献类型：期刊论文
| 作者 | Chen, JY ; Wang, DL ; Xi, JF ; Au, L ; Siekkinen, A ; Warsen, A ; Li, ZY ; Zhang, H ; Xia, YN ; Li, XD |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2007 |
| 卷号 | 7期号:5页码:1318 |
| ISSN号 | 1530-6984 |
| 中文摘要 | Gold nanocages with a relatively small size (e.g., similar to 45 nm in edge length) have been developed, and the structure of these nanocages was tailored to achieve strong absorption in the near-infrared (NIR) region for photothermal cancer treatment. Numerical calculations show that the nanocage has a large absorption cross section of 3.48 x 10(-14) m(2), facilitating conversion of NIR irradiation into heat. The gold nanocages were conjugated with monoclonal antibodies (anti-HER2) to target epidermal growth factor receptors (EGFR) that are overexpressed on the surface of breast cancer cells (SK-BR-3). Our preliminary photothermal results show that the nanocages strongly absorb light in the NIR region with an intensity threshold of 1.5 W/cm(2) to induce thermal destruction to the cancer cells. In the intensity range of 1.5-4.7 W/cm(2), the circular area of damaged cells increased linearly with the irradiation power density. These results suggest that this new class of bioconjugated gold nanostructures, immuno gold nanocages, can potentially serve as an effective photothermal therapeutic agent for cancer treatment. |
| 收录类别 | SCI |
| 公开日期 | 2013-09-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/39625]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen, JY,Wang, DL,Xi, JF,et al. Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells[J]. NANO LETTERS,2007,7(5):1318. |
| APA | Chen, JY.,Wang, DL.,Xi, JF.,Au, L.,Siekkinen, A.,...&Li, XD.(2007).Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells.NANO LETTERS,7(5),1318. |
| MLA | Chen, JY,et al."Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells".NANO LETTERS 7.5(2007):1318. |
入库方式： OAI收割
来源：物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。