Intriguing self-assembly of large granules of F-actin facilitated by gelsolin and alpha-actinin
文献类型：期刊论文
| 作者 | Tang, JX ; Kang, HR ; Jia, JF |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2005 |
| 卷号 | 21期号:7页码:2789 |
| 关键词 | MECHANICAL-PROPERTIES CROSS-LINKING THERMAL FLUCTUATIONS BUNDLE FORMATION FILAMENTS PROTEINS MUSCLE TROPOMYOSIN DETERMINES PHALLOIDIN |
| ISSN号 | 0743-7463 |
| 通讯作者 | Tang, JX: Brown Univ, Dept Phys, 184 Hope St, Providence, RI 02912 USA. |
| 中文摘要 | We report microscopic observations and a structural determination of actin granules self-assembled in concentrated solutions of actin filaments (F-actin). Optical microscopy shows reproducible formation of numerous and stable granules of densely packed F-actin of variable sizes on the order of 10 mu m. These granules coexist with a uniform network of F-actin of a lower concentration. The microscopic segregation of F-actin into two distinct states is assisted by an actin cross-linking protein, alpha-actinin. The rapid on and off rates and temperature sensitivity of the alpha-actinin/F-actin interaction facilitate the formation of multi-micrometer-sized granules of well-defined shapes. Additional physical factors such as the excluded volume effect and the minimization of surface energy act in concert with the specific molecular interactions to define the intriguing granular formation. Both the biochemical specificity of alpha-actinin and the thermodynamics of phase transitions are required for understanding such large scale self-assembly. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/40203]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Tang, JX,Kang, HR,Jia, JF. Intriguing self-assembly of large granules of F-actin facilitated by gelsolin and alpha-actinin[J]. LANGMUIR,2005,21(7):2789. |
| APA | Tang, JX,Kang, HR,&Jia, JF.(2005).Intriguing self-assembly of large granules of F-actin facilitated by gelsolin and alpha-actinin.LANGMUIR,21(7),2789. |
| MLA | Tang, JX,et al."Intriguing self-assembly of large granules of F-actin facilitated by gelsolin and alpha-actinin".LANGMUIR 21.7(2005):2789. |
入库方式： OAI收割
来源：物理研究所
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