Limping of homodimeric kinesin motors
文献类型：期刊论文
| 作者 | Xie, P ; Dou, SX ; Wang, PY |
| 刊名 | JOURNAL OF MOLECULAR BIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 366期号:3页码:976 |
| 关键词 | HAND-OVER-HAND MOLECULAR MOTORS DIMERIC KINESIN ATP HYDROLYSIS FORCE CLAMP MOVEMENT MICROTUBULE MECHANISM STEP PROTEINS |
| ISSN号 | 0022-2836 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Lab Soft Matter Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100080, Peoples R China. |
| 中文摘要 | Conventional kinesin, a homodimeric motor protein that transports cargo in various cells, walks limpingly along microtubule. Here, based on our previously proposed partially coordinated hand-over-hand model, we present a new mechanism for the limping behaviors of both wild-type and mutant kinesin homodimers. The limping is caused by different vertical forces acting on the heads in two successive steps during the processive movement of the dimer. From the model, various theoretical results, such as the dependences of the mean dwell time and dwell time ratio on the coiled-coil length and on the external load as well as the effect of vertical force on velocity are in good agreement with previous experimental results. We predict that a high degree of limping will correlate strongly with a high sensitivity of ATP turnover rate to upwards force. (c) 2006 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/40858]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P,Dou, SX,Wang, PY. Limping of homodimeric kinesin motors[J]. JOURNAL OF MOLECULAR BIOLOGY,2007,366(3):976. |
| APA | Xie, P,Dou, SX,&Wang, PY.(2007).Limping of homodimeric kinesin motors.JOURNAL OF MOLECULAR BIOLOGY,366(3),976. |
| MLA | Xie, P,et al."Limping of homodimeric kinesin motors".JOURNAL OF MOLECULAR BIOLOGY 366.3(2007):976. |
入库方式： OAI收割
来源：物理研究所
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