Mechanical properties of breast cancer cell membrane studied with optical tweezers
文献类型：期刊论文
| 作者 | Guo, HL ; Liu, CX ; Duan, JF ; Jiang, YQ ; Han, XH ; Li, ZH ; Cheng, BY ; Zhang, DZ |
| 刊名 | CHINESE PHYSICS LETTERS
 |
| 出版日期 | 2004 |
| 卷号 | 21期号:12页码:2543 |
| 关键词 | TETHER FORMATION GLYCOPROTEINS DISPLACEMENT RESERVOIR SURFACE FORCE |
| ISSN号 | 0256-307X |
| 通讯作者 | Guo, HL: Chinese Acad Sci, Inst Phys, Opt Phys Lab, Beijing 100080, Peoples R China. |
| 中文摘要 | Membrane tethers are extracted from breast cancer cells using a force generated by an optical trap. It is experimentally obtained that the radius of tether is about 0.1 mum and the static tether force is about 8.5 pN. Calculations based on the experimental measurements give a bending modulus for the tether of 1.35 x 10(-19) N.m and a surface membrane tension of 6.76 x 10(-6) N/m in the breast cancer cell. The treatment with cytochalasin D results in the decreasing bending modulus and decreasing apparent surface tension. When the membrane protein caveolin is over-expressed, similar cases occur in bending modulus and apparent surface tension. In addition, the viscous resistance coefficient of the membrane is calculated to be 1.15 pN.s/mum according to the dynamic tether forces obtained under different pulling velocities. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/41864]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guo, HL,Liu, CX,Duan, JF,et al. Mechanical properties of breast cancer cell membrane studied with optical tweezers[J]. CHINESE PHYSICS LETTERS,2004,21(12):2543. |
| APA | Guo, HL.,Liu, CX.,Duan, JF.,Jiang, YQ.,Han, XH.,...&Zhang, DZ.(2004).Mechanical properties of breast cancer cell membrane studied with optical tweezers.CHINESE PHYSICS LETTERS,21(12),2543. |
| MLA | Guo, HL,et al."Mechanical properties of breast cancer cell membrane studied with optical tweezers".CHINESE PHYSICS LETTERS 21.12(2004):2543. |
入库方式： OAI收割
来源：物理研究所
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