Mechanochemical couplings of kinesin motors
文献类型：期刊论文
| 作者 | Xie, P ; Dou, SX ; Wang, PY |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2006 |
| 卷号 | 123期号:1页码:58 |
| 关键词 | HAND-OVER-HAND STIMULATED ATP HYDROLYSIS MOLECULAR MOTORS DIMERIC KINESIN BROWNIAN MOTOR FORCE CLAMP 8-NM STEP SINGLE MICROTUBULE MOVEMENT |
| ISSN号 | 0301-4622 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, Beijing 100080, Peoples R China. |
| 中文摘要 | Kinesins are molecular motors capable of moving processively along microtubule in a stepwise manner by hydrolyzing ATP. Numerous experimental results on various aspects of their dynamical behaviours are available in literature. Although a number of models of tightly coordinated mechanism have been proposed to explain some experimental results, up to now no good explanation has been given to all these experimental results by using a single model. We have recently proposed such a model of partially coordinated hand-over-hand moving mechanism. In this paper, we use this model to study in detail various aspects of the dynamical properties of single kinesin molecules. We show that kinesin dimers walk hand-over-hand along microtubules in a partially coordinated rather than a tightly coordinated manner. The degree of coordination depends on the ratio of the two heads' ATPase rates that are in turn determined by both internal elastic force and external load. We have tested this model using various available experimental results on different samples and obtained a good agreement between the theory and the experiments. (c) 2006 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/41889]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P,Dou, SX,Wang, PY. Mechanochemical couplings of kinesin motors[J]. BIOPHYSICAL CHEMISTRY,2006,123(1):58. |
| APA | Xie, P,Dou, SX,&Wang, PY.(2006).Mechanochemical couplings of kinesin motors.BIOPHYSICAL CHEMISTRY,123(1),58. |
| MLA | Xie, P,et al."Mechanochemical couplings of kinesin motors".BIOPHYSICAL CHEMISTRY 123.1(2006):58. |
入库方式： OAI收割
来源：物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。