Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology
文献类型：期刊论文
| 作者 | Bjerrum, JT ; Nielsen, OH ; Hao, FH ; Tang, HR ; Nicholson, JK ; Wang, YL ; Olsen, J |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 9期号:2页码:954 |
| 关键词 | INFLAMMATORY-BOWEL-DISEASE MAGNETIC-RESONANCE SPECTROSCOPY SPINNING H-1-NMR SPECTROSCOPY ACID-INDUCED COLITIS FACTOR-KAPPA-B CROHNS-DISEASE GENE-EXPRESSION COLONIC-MUCOSA METABOLISM GLUTAMINE |
| ISSN号 | 1535-3893 |
| 通讯作者 | Bjerrum, JT: Univ Copenhagen, Herlev Hosp, Med Sect, Dept Gastroenterol, Herlev Ringvej 75, DK-2730 Herlev, Denmark. |
| 中文摘要 | Nuclear magnetic resonance (NMR) spectroscopy and appropriate multivariate statistical analyses have been employed on mucosal colonic biopsies, colonocytes, lymphocytes, and urine from patients with ulcerative colitis (UC) and controls in order to explore the diagnostic possibilities, define new potential biomarkers, and generate a better understanding of the pathophysiology. Samples were collected from patients with active UC (n = 41), quiescent UC (n = 33), and from controls (n = 25) and analyzed by NMR spectroscopy. Data analysis was carried out by principal component analysis and orthogonal-projection to latent structure-discriminant analysis using the SIMCA P+11 software package (Umetrics, Umea, Sweden) and Matlab environment. Significant differences between controls and active UC were discovered in the metabolic profiles of biopsies and colonocytes. In the biopsies from patients with active UC higher levels of antioxidants and of a range of amino acids, but lower levels of lipid, glycerophosphocholine (GPC), myo-inositol, and betaine were found, whereas the colonocytes only displayed low levels of GPC, myo-inositol and choline. Interestingly, 20% of inactive UC patients had similar profiles to those who were in an active state. This study demonstrates the possibilities of metabonomics as a diagnostic tool in active and quiescent UC and provides new insight into pathophysiologic mechanisms. |
| 收录类别 | SCI |
| 资助信息 | Fonden til Laegevidenskabens Frernme (the A.P. Moller Foundation); Danish Research Council [22-04-0622]; Augustinus Foundation; Aase and Ejnar Danielsen's Foundation; Foundation of Graduate Engineer Frode V Nyegaard and spouse; National Natural Science Foundation of China [20775087] |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/41917]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Bjerrum, JT,Nielsen, OH,Hao, FH,et al. Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology[J]. JOURNAL OF PROTEOME RESEARCH,2010,9(2):954. |
| APA | Bjerrum, JT.,Nielsen, OH.,Hao, FH.,Tang, HR.,Nicholson, JK.,...&Olsen, J.(2010).Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology.JOURNAL OF PROTEOME RESEARCH,9(2),954. |
| MLA | Bjerrum, JT,et al."Metabonomics in Ulcerative Colitis: Diagnostics, Biomarker Identification, And Insight into the Pathophysiology".JOURNAL OF PROTEOME RESEARCH 9.2(2010):954. |
入库方式： OAI收割
来源：物理研究所
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