Model for kinetics of myosin-V molecular motors
文献类型：期刊论文
| 作者 | Xie, P ; Dou, SX ; Wang, PY |
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2006 |
| 卷号 | 120期号:3页码:225 |
| 关键词 | HAND-OVER-HAND STRUCTURAL DYNAMICS MUSCLE-CONTRACTION SMOOTH-MUSCLE ADP RELEASE PROCESSIVITY MECHANISM KINESIN ACTIN ACTOMYOSIN |
| ISSN号 | 0301-4622 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, POB 603, Beijing 100080, Peoples R China. |
| 中文摘要 | A hand-over-hand model is presented for the processive movement of rnyosin-V based on previous biochemical experimental results and structural observations of nucleotide-dependent conformational changes of single-headed myosins. The model shows that the ADP-release rate of the trailing head is much higher than that of the leading head, thus giving a 1 : 1 mechanochernical coupling for the processive movement of the motor. It explains well the previous finding that some 36-nm steps consist of two substeps, while other 36-nm steps consist of no substeps. Using the model, the calculated kinetic behaviors of myosin-V such as the main and intermediate dwell time distributions, the load dependence of the average main and intermediate dwell time and the load dependence of occurrence frequency of the intermediate state under various nucleotide conditions show good quantitative agreement with previous experimental results. (c) 2005 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/42204]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P,Dou, SX,Wang, PY. Model for kinetics of myosin-V molecular motors[J]. BIOPHYSICAL CHEMISTRY,2006,120(3):225. |
| APA | Xie, P,Dou, SX,&Wang, PY.(2006).Model for kinetics of myosin-V molecular motors.BIOPHYSICAL CHEMISTRY,120(3),225. |
| MLA | Xie, P,et al."Model for kinetics of myosin-V molecular motors".BIOPHYSICAL CHEMISTRY 120.3(2006):225. |
入库方式： OAI收割
来源：物理研究所
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