Model for processive movement of myosin V and myosin VI
文献类型：期刊论文
| 作者 | Xie, P ; Dou, SX ; Wang, PY |
| 刊名 | CHINESE PHYSICS
 |
| 出版日期 | 2005 |
| 卷号 | 14期号:4页码:744 |
| 关键词 | MOTOR DOMAIN DETERMINES ACTIN-BASED MOTOR MOLECULAR MOTORS LARGE STEP KINETIC MECHANISM BACKWARDS KINESIN WALK |
| ISSN号 | 1009-1963 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Inst Phys, Lab Soft Matter Phys, POB 603, Beijing 100080, Peoples R China. |
| 中文摘要 | Myosin V and myosin VI are two classes of two-headed molecular motors of the myosin superfamily that move processively along helical actin filaments in opposite directions. Here we present a hand-over-hand model for their processive movements. In the model, the moving direction of a dimeric molecular motor is automatically determined by the relative orientation between its two heads at free state and its head's binding orientation on track filament. This determines that myosin V moves toward the barbed end and myosin VI moves toward the pointed end of actin. During the moving period in one step, one head remains bound to actin for myosin V whereas two heads are detached for myosin VI: the moving manner is determined by the length of neck domain. This naturally explains the similar dynamic behaviours but opposite moving directions of myosin VI and mutant myosin V (the neck of which is truncated to only one-sixth of the native length). Because of different moving manners, myosin VI and mutant myosin V exhibit significantly broader step-size distribution than native myosin V. However, all the three motors give the same mean step size of similar to 36nm (the pseudo-repeat of actin helix). All these theoretical results are in agreement with previous experimental ones. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/42206]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P,Dou, SX,Wang, PY. Model for processive movement of myosin V and myosin VI[J]. CHINESE PHYSICS,2005,14(4):744. |
| APA | Xie, P,Dou, SX,&Wang, PY.(2005).Model for processive movement of myosin V and myosin VI.CHINESE PHYSICS,14(4),744. |
| MLA | Xie, P,et al."Model for processive movement of myosin V and myosin VI".CHINESE PHYSICS 14.4(2005):744. |
入库方式： OAI收割
来源：物理研究所
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