Model for unidirectional movement of axonemal and cytoplasmic dynein molecules
文献类型：期刊论文
| 作者 | Xie, P ; Dou, SX ; Wang, PY |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2006 |
| 卷号 | 38期号:10页码:711 |
| 关键词 | MICROTUBULE-BINDING DOMAIN STATE KINETIC-ANALYSIS ADENOSINE-TRIPHOSPHATASE NUCLEOTIDE-BINDING ATP HYDROLYSIS HEAVY-CHAIN ADP RELEASE MOTOR KINESIN FORCE |
| ISSN号 | 1672-9145 |
| 通讯作者 | Xie, P: Chinese Acad Sci, Inst Phys, Lab Soft Matter Phys, Beijing Natl Lab Condensed Matter Phys, POB 603, Beijing 100080, Peoples R China. |
| 中文摘要 | A model for the unidirectional movement of dynein is presented based on the structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule (MT) is independent of its nucleotide state and the change between strong and weak MT-binding is determined naturally by the variation of relative orientation between the stalk and MT, as the stalk rotates following nucleotide-state transition. Thus the enigmatic communication from the adenosine triphosphate (ATP)-binding site in the globular domain to the far MT-binding site in the tip of the stalk, which is a prerequisite in conventional models, is not required. Using the present model, the previous experimental results such as the effect of ATP and adenosine diphosphate (ADP) bindings on dissociation of dynein from MT, the movement of single-headed axonemal dyneins at saturating ATP concentration, the load dependence of step-size for the movement of two-headed cytoplasmic dyneins and the dependence of stall force on ATP concentration can be well explained. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-18 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/42209]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P,Dou, SX,Wang, PY. Model for unidirectional movement of axonemal and cytoplasmic dynein molecules[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2006,38(10):711. |
| APA | Xie, P,Dou, SX,&Wang, PY.(2006).Model for unidirectional movement of axonemal and cytoplasmic dynein molecules.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,38(10),711. |
| MLA | Xie, P,et al."Model for unidirectional movement of axonemal and cytoplasmic dynein molecules".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 38.10(2006):711. |
入库方式： OAI收割
来源：物理研究所
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