The histone octamer influences the wrapping direction of DNA on it: Brownian dynamics simulation of the nucleosome chirality
文献类型：期刊论文
| 作者 | Wei, L ; Dou, SX ; Wang, PY |
| 刊名 | JOURNAL OF THEORETICAL BIOLOGY
 |
| 出版日期 | 2005 |
| 卷号 | 235期号:3页码:365 |
| 关键词 | INDIVIDUAL NUCLEOSOMES CHROMATIN FIBERS LINKER HISTONES CONDENSATION DISRUPTION REVEALS |
| ISSN号 | 0022-5193 |
| 通讯作者 | Wang, PY (reprint author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Lab Soft Matter Phys, Beijing 100080, Peoples R China. |
| 中文摘要 | In eukaryote nucleosome, DNA wraps around a historic octamer in a left-handed way. We study the process of chirality formation of nucleosome with Brownian dynamics simulation. We model the historic octamer with a quantitatively adjustable chirality: left-handed, right-handed or non-chiral, and simulate the dynamical wrapping process of a DNA molecule on it. We find that the chirality of a nucleosome formed is strongly dependent on that of the historic octamer, and different chiralities of the histone octamer induce its different rotation directions in the wrapping process of DNA. In addition, a very weak chirality of the historic octamer is quite enough for sustaining the correct chirality of the nucleosome formed. We also show that the chirality of a nucleosome may be broken at elevated temperature. © 2005 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-23 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/45208]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wei, L,Dou, SX,Wang, PY. The histone octamer influences the wrapping direction of DNA on it: Brownian dynamics simulation of the nucleosome chirality[J]. JOURNAL OF THEORETICAL BIOLOGY,2005,235(3):365. |
| APA | Wei, L,Dou, SX,&Wang, PY.(2005).The histone octamer influences the wrapping direction of DNA on it: Brownian dynamics simulation of the nucleosome chirality.JOURNAL OF THEORETICAL BIOLOGY,235(3),365. |
| MLA | Wei, L,et al."The histone octamer influences the wrapping direction of DNA on it: Brownian dynamics simulation of the nucleosome chirality".JOURNAL OF THEORETICAL BIOLOGY 235.3(2005):365. |
入库方式： OAI收割
来源：物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。