Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase
文献类型：期刊论文
| 作者 | Cazier, JB ; Kaisaki, PJ ; Argoud, K ; Blaise, BJ ; Veselkov, K ; Ebbels, TMD ; Tsang, T ; Wang, YL ; Bihoreau, MT ; Mitchell, SC ; Holmes, EC ; Lindon, JC ; Scott, J ; Nicholson, JK ; Dumas, ME ; Gauguier, D |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 11期号:2页码:631 |
| 关键词 | INSULIN-RESISTANT MICE SYSTEMS BIOLOGY METABONOMICS |
| ISSN号 | 1535-3893 |
| 通讯作者 | Gauguier, D (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England. |
| 中文摘要 | With successes of genome-wide association studies, molecular phenotyping systems are developed to identify genetically determined disease-associated biomarkers. Genetic studies of the human metabolome are emerging but exclusively apply targeted approaches, which restricts the analysis to a limited number of well known metabolites. We have developed novel technical and statistical methods for systematic and automated quantification of untargeted NMR spectral data designed to perform robust and accurate quantitative trait locus (QTL) mapping of known and previously unreported molecular compounds of the metabolome. For each spectral peak, six summary statistics were calculated and independently tested for evidence of genetic linkage in a cohort of F2 (129S6xBALB/c) mice. The most significant evidence of linkages were obtained with NMR signals characterizing the glycerate (LOD10-42) at the mutant glycerate kinase locus, which demonstrate the power of metabolomics in quantitative genetics to identify the biological function of genetic variants. These results provide new insights into the resolution of the complex nature of metabolic regulations and novel analytical techniques that maximize the full utilization of metabolomic spectra in human genetics to discover mappable disease-associated biomarkers. |
| 收录类别 | SCI |
| 资助信息 | Wellcome Trust [066786, 090532/Z/09/Z]; European Commission [LSHG-CT-2006-037683, FP7/2007-2013, HEALTH-F4-2010-241504]; Agence Nationale pour la Recherche [ANR-08-GENOPAT-030]; Institut National du Cancer [INCa-2008-060]; Agence Nationale de la Recherche in Chemistry [ANR-07-JCJC-0042]; Wellcome senior fellowship in basic biomedical science [057733] |
| 语种 | 英语 |
| 公开日期 | 2013-09-23 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/46435]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cazier, JB,Kaisaki, PJ,Argoud, K,et al. Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(2):631. |
| APA | Cazier, JB.,Kaisaki, PJ.,Argoud, K.,Blaise, BJ.,Veselkov, K.,...&Gauguier, D.(2012).Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase.JOURNAL OF PROTEOME RESEARCH,11(2),631. |
| MLA | Cazier, JB,et al."Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase".JOURNAL OF PROTEOME RESEARCH 11.2(2012):631. |
入库方式： OAI收割
来源：物理研究所
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