X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide
文献类型：期刊论文
| 作者 | Feng, YJ ; Qi, JX ; Zhang, HM ; Wang, JZ ; Liu, JH ; Jiang, F ; Gao, F |
| 刊名 | ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 62页码:13 |
| 关键词 | CLASS-I MOLECULE SIMIAN IMMUNODEFICIENCY VIRUS CRYSTALLIZATION EPITOPE |
| ISSN号 | 1744-3091 |
| 通讯作者 | Gao, F (reprint author), Chinese Acad Sci, Inst Microbiol, Lab Mol Immunol & Mol Virol, Beijing 100080, Peoples R China. |
| 中文摘要 | Simian immunodeficiency virus (SIV) in the rhesus macaque is regarded as a classic animal model, playing a crucial role in HIV vaccine strategies and therapeutics by characterizing various cytotoxic T-lymphocyte (CTL) responses in macaque monkeys. However, the availability of well documented structural reports focusing on rhesus macaque major histocompatibility complex class I (MHC I) molecules remains extremely limited. Here, a complex of the rhesus macaque MHC I molecule (Mamu-A*02) with human beta(2)m and an immunodominant SIV-Gag nonapeptide, GESNLKSLY (GY9), has been crystallized. The crystal diffracts X-rays to 2.7 angstrom resolution and belongs to space group C2, with unit-cell parameters a = 124.11, b = 110.45, c = 100.06 angstrom, and contains two molecules in the asymmetric unit. The availability of the structure, which is being solved by molecular replacement, will provide new insights into rhesus macaque MHC I (Mamu-A*02) presenting pathogenic SIV peptides. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-23 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/46689]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng, YJ,Qi, JX,Zhang, HM,et al. X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide[J]. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,2006,62:13. |
| APA | Feng, YJ.,Qi, JX.,Zhang, HM.,Wang, JZ.,Liu, JH.,...&Gao, F.(2006).X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide.ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS,62,13. |
| MLA | Feng, YJ,et al."X-ray crystallographic characterization of rhesus macaque MHC Mamu-A*02 complexed with an immunodominant SIV-Gag nonapeptide".ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 62(2006):13. |
入库方式： OAI收割
来源：物理研究所
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