Neuronal tau induces DNA conformational changes observed by atomic force microscopy
文献类型：期刊论文
| 作者 | Qu, MH ; Li, H ; Tian, R ; Nie, CL ; Liu, Y ; Han, BS ; He, RQ |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2004 |
| 卷号 | 15期号:18页码:2723 |
| 关键词 | PAIRED HELICAL FILAMENTS REPLICATION FACTOR-C PROTEIN-TAU PC12 CELLS CHROMATIN BINDING KINASES NUCLEAR ACID |
| ISSN号 | 0959-4965 |
| 通讯作者 | He, RQ (reprint author), Chinese Acad Sci, Inst Biophys, Ctr Brain & Cognit Sci, Lab Visual Informat Proc, 15 Datun Rd,Chaoyang Dist, Beijing 100101, Peoples R China. |
| 中文摘要 | Neuronal tau associates with chromosome scaffold and localizes in the nuclear and the nucleolar organization regions in neuronal and some non-neuronal cells. Observing the interaction of neuronal tau with DNA under AFM shows that tau binds to DNA as a monomer, and tau-DNA complex forms a beads-on-a-string structure when the mass ratio is 1:10 (molar ratio of tau/DNA similar to1:700 bp). A beads-on-a-coil structure, in which tau is as polymers, will appear when the mass ratio is up to 1:5 (molar ratio of tau/DNA similar to1:350 bp). The present observation that neuronal tau bends the DNA double strands indicates that the appearance of the tau-DNA complex is dependent upon the mass (or molar) ratio of tau and DNA. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/49807]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Qu, MH,Li, H,Tian, R,et al. Neuronal tau induces DNA conformational changes observed by atomic force microscopy[J]. NEUROREPORT,2004,15(18):2723. |
| APA | Qu, MH.,Li, H.,Tian, R.,Nie, CL.,Liu, Y.,...&He, RQ.(2004).Neuronal tau induces DNA conformational changes observed by atomic force microscopy.NEUROREPORT,15(18),2723. |
| MLA | Qu, MH,et al."Neuronal tau induces DNA conformational changes observed by atomic force microscopy".NEUROREPORT 15.18(2004):2723. |
入库方式： OAI收割
来源：物理研究所
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