On chemomechanical coupling of the F-1-ATPase molecular motor
文献类型：期刊论文
| 作者 | Xie, P |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
 |
| 出版日期 | 2009 |
| 卷号 | 1787期号:7页码:955 |
| 关键词 | ATP SYNTHASE CATALYSIS ESCHERICHIA-COLI ENERGY TRANSDUCTION HOLLIDAY JUNCTIONS BRANCH MIGRATION F-ATPASE ROTATION MECHANISM DNA HYDROLYSIS |
| ISSN号 | 0005-2728 |
| 通讯作者 | Xie, P (reprint author), Chinese Acad Sci, Inst Phys, Lab Soft Matter Phys, Beijing 100190, Peoples R China. |
| 中文摘要 | F-1-ATPase catalyzes ATP hydrolysis to drive the central gamma-shaft rotating inside a hexameric cylinder composed of alternating alpha and beta subunits. Experiments showed that the rotation of gamma-shaft proceeds in steps of 120 degrees and each 120 degrees-rotation is composed of an 80 degrees substep, and a 40 degrees substep. Here, based on the previously proposed models, an improved physical model for chemomechanical coupling of F-1-ATPase is presented, with which the two-substep rotation is well explained. One substep, is driven by the power stroke upon ATP binding, while the other one resulted from the passage of gamma-shaft from previous to next adjacent beta subunits via free diffusion. Using the model, the dynamics and kinetics of F-1-ATPase, such as the rotating time of each substep, the dwell time at each pause and the rotation rate, are analytically studied. The theoretical results obtained with only three adjustable parameters reproduce the available experimental data well. (C) 2009 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/50208]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P. On chemomechanical coupling of the F-1-ATPase molecular motor[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS,2009,1787(7):955. |
| APA | Xie, P.(2009).On chemomechanical coupling of the F-1-ATPase molecular motor.BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS,1787(7),955. |
| MLA | Xie, P."On chemomechanical coupling of the F-1-ATPase molecular motor".BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1787.7(2009):955. |
入库方式： OAI收割
来源：物理研究所
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