Stepping behavior of two-headed kinesin motors
文献类型：期刊论文
| 作者 | Xie, P |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
 |
| 出版日期 | 2008 |
| 卷号 | 1777期号:9页码:1195 |
| 关键词 | HAND-OVER-HAND ATP HYDROLYSIS CRYOELECTRON MICROSCOPY TUBULIN-BINDING PROTEIN COMPLEX MECHANISM MICROTUBULES MOLECULES PROCESSIVITY MOVEMENT |
| ISSN号 | 0005-2728 |
| 通讯作者 | Xie, P (reprint author), Chinese Acad Sci, Inst Phys, Lab Soft Matter Phys, POB 603, Beijing 100080, Peoples R China. |
| 中文摘要 | The stepping behavior of the dimeric kinesin is studied by using our model based on previous biochemical, Xray crystallography and cryo-electron microscopy studies. It is shown that, when a Pi is released from the trailing head. a forward step is made under a backward load smaller than the stall force: while when a Pi is released from the leading head, no stepping is made under a forward load or no load, and a backward step is made under a backward load. The forward stepping time, i.e., the time from the release of Pi in the trailing head to the binding of the ADP head to next binding site, is much smaller than the dwell time even under the backward load near the stall force. Thus the movement velocity of the kinesin dimer can be considered to be only dependent on ATPase rates of the two heads. The duration of the rising phase, i.e., the actual time taken by the ADP head to transit from the trailing to leading positions, is on the time scale of microseconds under any backward load smaller than the stall force. This is consistent with available experimental results. (C) 2008 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/53069]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xie, P. Stepping behavior of two-headed kinesin motors[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS,2008,1777(9):1195. |
| APA | Xie, P.(2008).Stepping behavior of two-headed kinesin motors.BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS,1777(9),1195. |
| MLA | Xie, P."Stepping behavior of two-headed kinesin motors".BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1777.9(2008):1195. |
入库方式： OAI收割
来源：物理研究所
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