Study on bio-corrosion and cytotoxicity of a sr-based bulk metallic glass as potential biodegradable metal
文献类型：期刊论文
| 作者 | Li, HF ; Zhao, K ; Wang, YB ; Zheng, YF ; Wang, WH |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
 |
| 出版日期 | 2012 |
| 卷号 | 100B期号:2页码:368 |
| 关键词 | REBALANCING BONE TURNOVER STRONTIUM SALT S12911 HA BIOACTIVE CEMENT DUAL-MODE IN-VITRO MAGNESIUM ALLOYS TISSUE-CULTURE GROWING RATS ZR ADDITIONS RESISTANCE |
| ISSN号 | 1552-4973 |
| 通讯作者 | Zheng, YF (reprint author), Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing 100871, Peoples R China. |
| 中文摘要 | In this study, a novel Sr-based bulk metallic glass (BMG) with nominal composition of Sr40Mg20Zn15Yb20Cu5 (at.%) was fabricated with high-purity raw materials by induction-melting method. Its mechanical properties, corrosion behavior, and cellular compatibility were studied in vitro as a feasibility evaluation of potential biodegradable metal. The compression strength of Sr40Mg20Zn15Yb20Cu5 alloy was (408.2 +/- 20.0) MPa, which was much higher than human bone (164240 MPa). Its Young's modulus (20.6 +/- 0.2) GPa was quite close to human bone (523 GPa). MTT assay and PNPP method were employed to measure the proliferation ability and ALP activity of the experimental Sr-based BMG. The results 01 grade cytotoxicity and high ALP activity revealed that it was harmless to osteoblast-like MG63 cells. Additionally, the cells cultured on the surface of Sr40Mg20Zn15Yb20Cu5 alloy plate exhibited polygonal and dorsal ruffle configuration, and were well attached to the substrate by cellular extension, indicating their healthy status. The combination of increased mechanical strength, greater corrosion resistance, and excellent biocompatibility makes the Sr40Mg20Zn15Yb20Cu5 BMG very attractive material for biodegradable orthopedic implant applications. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 368377, 2012. |
| 收录类别 | SCI |
| 资助信息 | Research Fund for the Doctoral Program of Higher Education [20100001110011]; National High Technology Research and Development Program of China (863 Program) [2011AA030101, 2011AA030103]; National Basic Research Program of China (973 Program) [2012CB619102]; National Natural Science Foundation of China [30870623, 51041004]; Program for New Century Excellent Talents in University [NCET-07-0033] |
| 语种 | 英语 |
| 公开日期 | 2013-09-24 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/53830]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, HF,Zhao, K,Wang, YB,et al. Study on bio-corrosion and cytotoxicity of a sr-based bulk metallic glass as potential biodegradable metal[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2012,100B(2):368. |
| APA | Li, HF,Zhao, K,Wang, YB,Zheng, YF,&Wang, WH.(2012).Study on bio-corrosion and cytotoxicity of a sr-based bulk metallic glass as potential biodegradable metal.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,100B(2),368. |
| MLA | Li, HF,et al."Study on bio-corrosion and cytotoxicity of a sr-based bulk metallic glass as potential biodegradable metal".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 100B.2(2012):368. |
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来源：物理研究所
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