Alkanethiol-functionalized terahertz metamaterial as label-free, highly-sensitive and specific biosensor
文献类型：期刊论文
| 作者 | Wu, XJ ; Quan, BG ; Pan, XC ; Xu, XL ; Lu, XC ; Gu, CZ ; Wang, L |
| 刊名 | BIOSENSORS & BIOELECTRONICS
 |
| 出版日期 | 2013 |
| 卷号 | 42页码:626 |
| 关键词 | Biosensor Biospecification Metamaterial Terahertz spectroscopy |
| ISSN号 | 0956-5663 |
| 通讯作者 | Xu, XL (reprint author), NW Univ Xian, Inst Photon & Photon Technol, Xian 710069, Peoples R China. |
| 中文摘要 | Specific biorecognition is essential for many biological processes, for which highly sensitive and label-free biosensors are strongly demanded. The recently developed metamaterials are a potential choice for biosensing due to their exotic properties. In the current work, a label-free and specific sensor for streptavidin-agarose (SA) was fabricated based on terahertz metamaterial functionlized by octadecanthiols and biotins. Both low and high frequency resonant modes from the metamaterials are found applicable for the detection of SA, and a redshift up to 6.76 GHz for the high frequency mode was measured in the undiluted commercial solution. The low frequency mode is attributed to inductor-capacitor (LC) oscillation, while the high frequency mode originates from the plasmonic dipole oscillator, both of which are highly sensitive to the micro-environment change. Adsorption of SA of different concentrations causes different redshifts, and the replacement of high refractive-index substrate with low refractive-index substrate can efficiently promote the sensitivity, well agreeing with the numerical simulation. Moreover, for a particular biomolecule, the sensitivity can be further improved by optimizing the metamaterial design. This method might be very helpful for desirable biorecognition in biology, medicine, and drug industry. (C) 2012 Elsevier B.V. All rights reserved. |
| 资助信息 | National Natural Science Foundation of China [10834015, 61077082, 51103175]; Natural Science Basic Research Plan in Shaanxi Province of China [2012KJXX-27]; open foundation of State Key Lab Incubation Base of Photoelectric Technology and Functional Materials [ZS12018] |
| 语种 | 英语 |
| 公开日期 | 2014-01-16 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/56764]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu, XJ,Quan, BG,Pan, XC,et al. Alkanethiol-functionalized terahertz metamaterial as label-free, highly-sensitive and specific biosensor[J]. BIOSENSORS & BIOELECTRONICS,2013,42:626. |
| APA | Wu, XJ.,Quan, BG.,Pan, XC.,Xu, XL.,Lu, XC.,...&Wang, L.(2013).Alkanethiol-functionalized terahertz metamaterial as label-free, highly-sensitive and specific biosensor.BIOSENSORS & BIOELECTRONICS,42,626. |
| MLA | Wu, XJ,et al."Alkanethiol-functionalized terahertz metamaterial as label-free, highly-sensitive and specific biosensor".BIOSENSORS & BIOELECTRONICS 42(2013):626. |
入库方式： OAI收割
来源：物理研究所
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