Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation
文献类型：期刊论文
| 作者 | Paulk, AC ; Zhou, Y ; Stratton, P ; Liu, L ; van Swinderen, B |
| 刊名 | JOURNAL OF NEUROPHYSIOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 110期号:7页码:1703 |
| 关键词 | local field potential electrophysiology Drosophila behavior genetics coherence vision olfaction |
| ISSN号 | 0022-3077 |
| 通讯作者 | van Swinderen, B (reprint author), Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia. |
| 中文摘要 | Neural networks in vertebrates exhibit endogenous oscillations that have been associated with functions ranging from sensory processing to locomotion. It remains unclear whether oscillations may play a similar role in the insect brain. We describe a novel "whole brain" readout for Drosophila melanogaster using a simple multichannel recording preparation to study electrical activity across the brain of flies exposed to different sensory stimuli. We recorded local field potential (LFP) activity from >2,000 registered recording sites across the fly brain in >200 wild-type and transgenic animals to uncover specific LFP frequency bands that correlate with: 1) brain region; 2) sensory modality (olfactory, visual, or mechanosensory); and 3) activity in specific neural circuits. We found endogenous and stimulus-specific oscillations throughout the fly brain. Central (higher-order) brain regions exhibited sensory modality-specific increases in power within narrow frequency bands. Conversely, in sensory brain regions such as the optic or antennal lobes, LFP coherence, rather than power, best defined sensory responses across modalities. By transiently activating specific circuits via expression of TrpA1, we found that several circuits in the fly brain modulate LFP power and coherence across brain regions and frequency domains. However, activation of a neuromodulatory octopaminergic circuit specifically increased neuronal coherence in the optic lobes during visual stimulation while decreasing coherence in central brain regions. Our multichannel recording and brain registration approach provides an effective way to track activity simultaneously across the fly brain in vivo, allowing investigation of functional roles for oscillations in processing sensory stimuli and modulating behavior. |
| 资助信息 | Australian Research Council; Queensland Brain Institute |
| 语种 | 英语 |
| 公开日期 | 2014-01-16 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/57232]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Paulk, AC,Zhou, Y,Stratton, P,et al. Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation[J]. JOURNAL OF NEUROPHYSIOLOGY,2013,110(7):1703. |
| APA | Paulk, AC,Zhou, Y,Stratton, P,Liu, L,&van Swinderen, B.(2013).Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation.JOURNAL OF NEUROPHYSIOLOGY,110(7),1703. |
| MLA | Paulk, AC,et al."Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation".JOURNAL OF NEUROPHYSIOLOGY 110.7(2013):1703. |
入库方式： OAI收割
来源：物理研究所
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