Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules
文献类型：期刊论文
| 作者 | Zhang, HY ; Liu, YR ; Ji, C ; Li, W ; Dou, SX ; Xie, P ; Wang, WC ; Zhang, LY ; Wang, PY |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:8 |
| ISSN号 | 1932-6203 |
| 通讯作者 | Wang, PY (reprint author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Key Lab Soft Matter Phys, POB 603, Beijing 100080, Peoples R China. |
| 中文摘要 | The interactions of DNA with oxaliplatin (Pt(R, R-DACH)) or its enantiomer (Pt(S, S-DACH)) were investigated using magnetic tweezers and atomic force microscope. In the process of DNA condensation induced by Pt-DACH, only diadducts and micro-loops are formed at low Pt-DACH concentrations, while at high Pt-DACH concentrations, besides the diadducts and micro-loops, long-range cross-links are also formed. The diadduct formation rate of Pt(R, R-DACH) is higher than that of Pt(S, SDACH). However, the proportions of micro-loops and long-range cross-links for Pt(S, S-DACH) are higher than those for Pt(R, R-DACH). We propose a model to explain these differences between the effect of Pt(R, R-DACH) and that of Pt(S, SDACH) on DNA condensation. The study has strong implications for the understanding of the effect of chirality on the interaction between Pt-DACH and DNA and the kinetics of DNA condensation induced by platinum complexes. |
| 资助信息 | National Natural Science Foundation of China [11274374]; National Basic Research Program of China (973 Program) [2009CB930704] |
| 语种 | 英语 |
| 公开日期 | 2014-01-16 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/57309]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang, HY,Liu, YR,Ji, C,et al. Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules[J]. PLOS ONE,2013,8(8). |
| APA | Zhang, HY.,Liu, YR.,Ji, C.,Li, W.,Dou, SX.,...&Wang, PY.(2013).Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules.PLOS ONE,8(8). |
| MLA | Zhang, HY,et al."Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules".PLOS ONE 8.8(2013). |
入库方式： OAI收割
来源：物理研究所
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