The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes
文献类型：期刊论文
| 作者 | Fu, CH ; Liu, TL ; Li, LL ; Liu, HY ; Chen, D ; Tang, FQ |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:10页码:2565 |
| 关键词 | Mesoporous silica nanoparticles Toxicity Exposure routes Kinetics |
| ISSN号 | 0142-9612 |
| 通讯作者 | Tang, FQ (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Lab Controllable Preparat & Applicat Nanomat, 29 Zhongguancun East Rd, Beijing 100190, Peoples R China. |
| 中文摘要 | Mesoporous silica nanoparticles (MSNs) are emerging as one of the promising nanomaterials for biomedical applications, but the nanomaterials body interaction exposed by different administration routes remained poorly understood. In the present study, a systematic investigation of the absorption, distribution, excretion and toxicity of silica nanoparticles (SNs) with the average size of 110 nm after four different exposure routes including intravenous, hypodermic, intramuscular injection and oral administration to mice were achieved. The results showed that a fraction of the SNs administrated by the intramuscular and hypodermic injection could cross different biological barriers into the liver but with a low absorption rate. Exposing by oral administration, SNs were absorbed into the intestinal tract and persisted in the liver. And SNs administrated by intravenous injection were mainly present in the liver and spleen. In addition, SNs could cause inflammatory response around the injection sites after intramuscular and hypodermic injection. It was also found that SNs were mainly excreted through urine and feces after different exposure routes. This study will be helpful for selecting the appropriate exposed routes for the development of nanomaterials-based drug delivery system for biomedical applications. (C) 2013 Elsevier Ltd. All rights reserved. |
| 资助信息 | National Natural Science Foundation of China (NSFC) [81201814, 31270022, 81171454, 31271075]; Beijing Nova Program [Z111103054511113] |
| 语种 | 英语 |
| 公开日期 | 2014-01-17 |
| 源URL | [http://ir.iphy.ac.cn/handle/311004/57561]  |
| 专题 | 物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文 |
| 推荐引用方式 GB/T 7714 | Fu, CH,Liu, TL,Li, LL,et al. The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes[J]. BIOMATERIALS,2013,34(10):2565. |
| APA | Fu, CH,Liu, TL,Li, LL,Liu, HY,Chen, D,&Tang, FQ.(2013).The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes.BIOMATERIALS,34(10),2565. |
| MLA | Fu, CH,et al."The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes".BIOMATERIALS 34.10(2013):2565. |
入库方式： OAI收割
来源：物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。