Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish
文献类型：期刊论文
| 作者 | Wang Yang; Zhou Li; Li Zhi; Li WenHua; Gui JianFang |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 56期号:11页码:975-984 |
| 关键词 | epiboly apolipoprotein C1 E-cadherin radial intercalation |
| ISSN号 | 1674-7305 |
| 通讯作者 | Gui, JF (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. |
| 中文摘要 | Apolipoprotein C1 (Apoc1) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoc1b, a transcript isoform of Apoc1, in epiboly during zebrafish gastrulation. Apoc1b is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a radial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoc1b by injecting antisense morpholino (MO) caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the radial gradient distribution of E-cadherin are disrupted both in Apoc1b knockdown and overexpressed embryos. Therefore, Apoc1b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner. |
| 英文摘要 | Apolipoprotein C1 (Apoc1) is associated with lipoprotein metabolism, but its physiological role during embryogenesis is largely unknown. We reveal a new function of Apoc1b, a transcript isoform of Apoc1, in epiboly during zebrafish gastrulation. Apoc1b is expressed in yolk syncytial layers and in deep cells of the ventral and lateral region of the embryos. It displays a radial gradient with high levels in the interior layer and low levels in the superficial layer. Knockdown of Apoc1b by injecting antisense morpholino (MO) caused the epiboly arrest in deep cells. Moreover, we show that the radial intercalation and the radial gradient distribution of E-cadherin are disrupted both in Apoc1b knockdown and overexpressed embryos. Therefore, Apoc1b controls epiboly via E-cadherin-mediated radial intercalation in a gradient-dependent manner. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 关键词[WOS] | ORANGE-SPOTTED GROUPER ; CELL MOVEMENTS ; VERTEBRATE GASTRULATION ; MOLECULAR-CLONING ; E-CADHERIN ; EXPRESSION ; YOLK ; MICROFILAMENTS ; ORGANIZATION ; CYTOSKELETON |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China [2010CB126300]; National High Technology Research and Development Program of China [2012AA092201-3]; Ministry of Agriculture of China [200903045]; National Natural Science Foundation of China [30971414] |
| 语种 | 英语 |
| WOS记录号 | WOS:000326813300001 |
| 公开日期 | 2014-01-24 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/19772]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Yang,Zhou Li,Li Zhi,et al. Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish[J]. SCIENCE CHINA-LIFE SCIENCES,2013,56(11):975-984. |
| APA | Wang Yang,Zhou Li,Li Zhi,Li WenHua,&Gui JianFang.(2013).Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish.SCIENCE CHINA-LIFE SCIENCES,56(11),975-984. |
| MLA | Wang Yang,et al."Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish".SCIENCE CHINA-LIFE SCIENCES 56.11(2013):975-984. |
入库方式： OAI收割
来源：水生生物研究所
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